DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and ugt-57

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_509182.1	Gene:	ugt-57 / 180969	WormBaseID:	WBGene00017154	Length:	558	Species:	Caenorhabditis elegans

Alignment Length:	596	Identity:	142/596 - (23%)
Similarity:	236/596 - (39%)	Gaps:	129/596 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILFMKL--------LFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITP-- 55
            :||.:.|        :.|.||||....|.:..|             :.::|..|.|.|..|.|
Worm     4 LILLLGLTQIVTSLNILVFLLGTNQFERNIFEF-------------LAQQLALRHHNVISIKPVL 55

  Fly    56 -----------LSLAKENLGPNY--REILLPKYD-----TWA---DISAMMKTKSALDMIDMSKL 99
                       |.|.:|.:..|.  :::..|..|     .|.   |....::...........||
Worm    56 IPEEPRLVKPKLHLVREKVIKNVLNKDLFKPLEDAVPNAAWRSTYDFDNYLEPYYKAHNASCYKL 120

  Fly   100 THMRLAQHIGIKSTDF-----------ALAHPEVQELIYAKDKKGKFDL----------LLVEQF 143
            .:..|...:..:|.|.           ||.|......||. |.:|..|.          ||....
Worm   121 LNSNLVDSLKKESLDLAIVYSGNPCLNALTHLVAVPTIYF-DTEGLTDETLIAAGAPIDLLTPPS 184

  Fly   144 HNEGALMLGYIYEIPAITIATFAYAN---YFSQVFGFVNPLSYVPNV--FLSCTDRMSLWERLEN 203
            |...|...||    |.:.:    |.|   ||.::...:.    :|.|  .:|...|: |.|.:.|
Worm   185 HCFIAESKGY----PILNL----YKNSVCYFQEMIAQLG----LPAVSSLVSSRHRL-LDEPITN 236

  Fly   204 VVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNM 268
            :.               :.|..|:|.|.:.    |.|..|:|..:...:|:...|..||.:..|:
Worm   237 IF---------------RTDYTIKKRFKNF----PNVNTLKQQSAAYFVNTDPLLEPPRALPLNV 282

  Fly   269 ISVGGLHILPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQ-RVLW 332
            |.||||||..||||.......:.:|:.|.|..|.|:|..|:.|.....:..|....:|.. |:.|
Worm   283 IPVGGLHIDHPKPLFSPWNTTIASAKEGLIIVSFGTQADSSKMSEYHAKAILKALTNLNDYRIYW 347

  Fly   333 K------FEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFY 391
            :      .:...:..:|.::.:..::||.|:|||.:.|:|:.:||:..:.|||.|.||::|:|.|
Worm   348 RIGPNMHLDGIDIEKIPKHINLTTFIPQNDLLAHKSCKLFVTNGGMSSVMEAVAHGVPIVGVPLY 412

  Fly   392 FDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAM 456
            .....|::.....|..|.:|...:::..|..|:..:|:..||:....:.|:.|:.|.......|:
Worm   413 GSNRYNLQKVSNKGLGIVIDKDDLNEISLYGAMKKVLESAKYKNTAKEMSKEFKSRTTSPFAAAL 477

  Fly   457 YWINYVVEHRGAPHLVAAGVHLPWY---QFYLLDVSAIILAITLLPLLTLY--------AVSRNY 510
            :.|:::..|....::..|  ..|.|   .||||      |.|.|||::.|:        :.:.|.
Worm   478 HVIDHIGRHHSFAYMQPA--FQPIYTRVDFYLL------LLIILLPVIPLHLFFTFCIKSSAMNV 534

  Fly   511 KSFRGIRAQKK 521
            :..:.:.|::|
Worm   535 QDNKVLEAERK 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	138/567 (24%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	125/524 (24%)
ugt-57	NP_509182.1	GT1_Gtf-like	<168..477	CDD:340817	86/340 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910