DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-18

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_506209.2	Gene:	ugt-18 / 179759	WormBaseID:	WBGene00013900	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	134/548 - (24%)
Similarity:	229/548 - (41%)	Gaps:	86/548 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FMKLLFVCLLGTGDGARILAPFFLPV--KSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPN 66
            |..:||..|:.:....::|.  |.|.  .||......|...|:..||.||.:.|
Worm     3 FALILFFVLIHSTLTYKVLV--FNPAYGASHSNFLGKISDILIDAGHNVTMLIP----------- 54

  Fly    67 YREILLPKYDTWADISAMMKTKSALDMIDM------SKLTHMRLAQHIG---------------- 109
              |.|:.|.|       .:.:|...|::.:      .||......:|:|
Worm    55 --EYLITKKD-------FVGSKKVKDVVRIGRDERAGKLFEEEGIEHMGRARVWRMDPEMMSLVT 110

  Fly   110 -IKSTDFALAHPEVQELIYAKD-----KKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYA 168
             :.|.:.|:.: :.:.:...||     :...|||.:.|........:..:|    .|.....|.:
Worm   111 IVGSMNLAIGY-QCEYIFQQKDIIDRLRNEHFDLAITESLFACPFALFDHI----GIKNVINAES 170

  Fly   169 NYFSQVFGFVN----PLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKH 229
            |.|.....:.:    .:||.|.:|....|:||...|::|::.......:.. |.|.::..:|:.:
Worm   171 NLFKDAVKYAHGEPAAISYYPGLFSPHDDKMSFVARVKNMITMLFTKYLYG-SRYEKELEMIKPY 234

  Fly   230 FSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPK---PLPEHIKNYLD 291
            ::.    ..|.:.|...::..|:||...:..|.|.....:.|||:.:...:   .|.:...|.|
Worm   235 YNG----TETWEDLFTGVAFNLINSNQYIDYPSPALPKTVFVGGMQVNTNEAKTKLSDEWNNIL- 294

  Fly   292 NAEHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQ-RVLWKFEDDQ---LPNLPDNVKVEKWL 352
            |.....:..|.||...|::||.|..:.||.||.::.: ..:||:|:..   ..:|| |||:..|:
Worm   295 NIRKQNVLISFGSNAFSSEMPEEFKKSFLYVFGNMPEITFIWKYEEANATLTSHLP-NVKLTTWM 358

  Fly   353 PQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINI----KAGQAAGYAIGLDYR 413
            ||.|:||...:.:|:.||||....|..|...|.|.:|...||..|.    :.|....|     ::
Worm   359 PQNDLLADDRLTLFVTHGGLGSTMELAYQGKPALIIPLMADQPRNAHMLKRHGGCLQY-----HK 418

  Fly   414 TI--SKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGV 476
            |:  ..:||..|...:|.:.||..|..:.:||.||:|:...|..:....:.|||.....|.:.|.
Worm   419 TMLGDSEQLLKAFKTVLTERKYSENAQRLARILRDQPVSPKDLVLKHCEFAVEHGALNSLNSRGR 483

  Fly   477 HLPWYQFYLLDVSAIILAITLLPLLTLY 504
            :|..:|||..|:::.|:.:.||.|:.:|
Worm   484 YLNTFQFYSFDIASSIVMLALLVLVFIY 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	133/544 (24%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	123/510 (24%)
ugt-18	NP_506209.2	UDPGT	19..512	CDD:278624	130/532 (24%)
ugt-18	NP_506209.2	Glycosyltransferase_GTB_type	<252..504	CDD:299143	77/258 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161616
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.790