DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-11

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_504311.1	Gene:	ugt-11 / 178882	WormBaseID:	WBGene00020593	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	144/563 - (25%)
Similarity:	235/563 - (41%)	Gaps:	71/563 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MKLL-FVC---LLGTGDGARILAPFFLPV--KSHFMMTDAIIRELVKRGHEVTFITPLSLAKENL 63
            |:|| |.|   ||.....|:||  .|.|:  .||......:...:...|.|||...|..||.:||
Worm     1 MRLLTFSCLCFLLKVNYAAKIL--IFNPIFGFSHVKFVSKLADIIADHGQEVTLFQPFHLALKNL 63

  Fly    64 G---PNYREILLPKYDTWADISAMMKTKSALDMIDMSKLTH-----MRLAQHIG--IKSTDFALA 118
            .   .|....::..|....|....::|::..|..|...:.:     ..|.:.:|  .|.|...|.
Worm    64 DGIVKNKNIEIINYYPDHYDDLLKLETQTFPDFWDSQLMNNPVLMAFMLPRILGGEFKKTTIQLI 128

  Fly   119 HPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSY 183
             .:.:.|...|||  |||:.:.|.|...| :.:.:...:|.|.|.:....:.|::.||..:...|
Worm   129 -KDKEILKKLKDK--KFDVAISETFELTG-MYMSHFLGVPCIPILSAVRLDIFNEAFGQSSAFGY 189

  Fly   184 VPNVFLSCTDRMSLWERLENVVIS-TAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNI 247
            :..............:||.:|... .::...|.::.|  |:.||.|....:   ||..|.|.:..
Worm   190 LTQQGSKLAPDAGFLDRLNDVYRDFFSKMAFRGMAQY--QNDVIEKAAGHV---VPYWKDLVKEA 249

  Fly   248 SVILLNSYMPLTSPRPMSQNMISVGGLHILPPK-----PLPEHIKNYLDNAEHGAIYFSLGSQVR 307
            .|.:.||...|....|.:..::.:||:.|...|     .|||..:..|...| ..:..|.||.:|
Worm   250 PVYMTNSNPYLDFAVPTTATIVHIGGITINLEKMNHVDALPEEYEIILKEKE-TTVLISFGSVIR 313

  Fly   308 SADMPAEKLQIFLDVFASLKQRV-LWKFEDDQL---PNLPDNVKVEKWLPQADILAHPNVKVFIA 368
            |.:||.......:.||.||...: :||:|.|.|   ..||.||.::||:||..:||...||:|:.
Worm   314 SYEMPENFKAGLIKVFESLPDVIFIWKYEIDDLEFQKKLPKNVHLKKWVPQPSLLADKRVKLFVT 378

  Fly   369 HGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLD-YRTISKDQLKSALHALLKDPK 432
            ||||....|..|...|.|.:|.:.||.:|.......|.||..| :..:...:|...:..|:.:||
Worm   379 HGGLGSTMEVAYTGKPALMVPIFGDQPMNADMLARHGGAIAYDKFDLVDGKKLTETVRDLVTNPK 443

  Fly   433 YQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHL---------VAAGVHLPWYQFYLLDV 488
            |:....:...:..::|:..:...|..:.:.::.   |:|         |....|      |.|||
Worm   444 YEQKAKELLDVLTNQPIDPVMNLMKHLEFAIKF---PNLRSQIPEINQVGPIAH------YYLDV 499

  Fly   489 SAIILAITLLPLLTLYAVSRNYKSFRGI-----RAQKKEAKTE 526
            ...::.::::..         |.||:.:     |...|:.|::
Worm   500 IVFLIFVSIITA---------YISFQIVCRILSRILSKKVKSD 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	138/532 (26%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	126/495 (25%)
ugt-11	NP_504311.1	egt	<220..514	CDD:223071	85/317 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161655
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740