DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-24

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_500931.3	Gene:	ugt-24 / 177380	WormBaseID:	WBGene00016762	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	130/545 - (23%)
Similarity:	217/545 - (39%)	Gaps:	104/545 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LPVK----------SHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNYREILLPKYDTWADI 81
            ||.|          ||..:.:.:...|...||.||...|:..:.:          |.|
Worm    18 LPYKILIYSNLYGHSHIKVLNTVADTLTDAGHNVTIFRPIIESSQ----------LDK------- 65

  Fly    82 SAMMKTKSAL------DMID-MSKLTHMRLAQHIGIKSTDFALAHPEV----------------- 122
             :.:|||:.:      :::: |||:.     |..|...| |...||..
Worm    66 -SSVKTKNVIYIEPDEEVVEKMSKID-----QFSGSLWT-FDSTHPSAMIAKSNALVGFFGTQCK 123

  Fly   123 ----QELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFGFVNPLSY 183
                |:.|..:.:...|||.:.|........:..|:.....:|:.:....::.|.:.|.....||
Worm   124 KVMRQQKILDQLRDENFDLAITEPVDGCAYAIFEYLKIRDHVTVLSCVRFDHVSDILGQPIAPSY 188

  Fly   184 VPNVFLSCTDRMSLWERLENVV------ISTAEDVVREVSYYPQQDAV-IRKHFSSLLPRVPTVK 241
            ||.......|||::.|||.|.:      .:.|.  :.:..|...:|.: |::.:..:||..
Worm   189 VPGTQSFFNDRMTMKERLLNFIQFYYGRFTFAN--ILDQEYEMAKDILGIQRSWREVLPEA---- 247

  Fly   242 QLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIK-----NYLDNAEHGAIYFS 301
                  |.|..|....|..|.|....:|.:||..:   |...:.:|     :.:.|.....:..|
Worm   248 ------SFIFSNHIPVLDFPSPTFDKIIPIGGFTV---KTNEKSLKIDKKWDAILNIRKKNVLIS 303

  Fly   302 LGSQVRSADMPAEKLQIFLDVFASLKQRV-LWKFEDDQLPNLP-----DNVKVEKWLPQADILAH 360
            .||..:|.|||.|..:..|.||:|:.... :||:||   ||:.     |||.:..||||.::||.
Worm   304 FGSNAKSKDMPEEYKKTLLRVFSSMPDTTFIWKYED---PNVNIAKNLDNVFISSWLPQNELLAD 365

  Fly   361 PNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISK-DQLKSAL 424
            ..|.||:.||||..:.|......|.:.:|.:.||..|.:..:..|.|..|....:|. |.::..|
Worm   366 SRVTVFVTHGGLASVMELALMGKPAIMIPIFADQGRNAQMLKRHGGAAVLQKTDLSNFDLVRDTL 430

  Fly   425 HALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVS 489
            :.:|..|.|:.|..|.:.:..::|..|.:..:..:.:.......|.|...|.|....::|.:|:.
Worm   431 NDVLTKPSYKLNAKKLAEMLNNQPTNAKEVLVKHVEFAARFGKLPMLDNYGRHQNIVEYYFIDIL 495

  Fly   490 AIILAIT-----LLPLLTLYAVSRN 509
            .|||::.     :...|..:.:|||
Worm   496 TIILSVLISVFYIFVRLLRFMLSRN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	126/536 (24%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	123/517 (24%)
ugt-24	NP_500931.3	UDPGT	32..519	CDD:278624	124/528 (23%)
ugt-24	NP_500931.3	egt	<251..504	CDD:223071	72/258 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860