DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt-25

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_491438.1	Gene:	ugt-25 / 172087	WormBaseID:	WBGene00015692	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	532	Identity:	139/532 - (26%)
Similarity:	233/532 - (43%)	Gaps:	77/532 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 ILAPFFLPVKSHFM--MTDAIIRELVKRGHEVTFITPLS--LAKENLG-PNYREILLPKYDTWAD 80
            :.:|.|....::||  :.|.    |.:.||.|||:.|::  ..|..|| ...:::::.:.|
Worm    22 VYSPSFGGSHTNFMARLADT----LTEAGHNVTFVVPVADEARKGQLGVKKTKDVVIVEQD---- 78

  Fly    81 ISAMMKTK-SALDMIDMSKL--THMRLAQHIGIKS----------TDFALAHPEVQELIYAKDKK 132
              .:||:: ..|| .||::.  |.|..:....|.|          .:|........||     |.
Worm    79 --ELMKSEIKPLD-DDMAQYWETDMDSSNADSIFSVFSDAMLLSCNNFMRNKKVFNEL-----KS 135

  Fly   133 GKFDLLLVEQFHNEGALMLGYIYEIPAIT--IATFAYANYFSQVFGFVNPL--SYVPNVFLSCTD 193
            ..||:.:.|.....|   |||::.| .|.  |.:.:.|.|...|.....|:  ||||.......:
Worm   136 RNFDVGIYEPLSVCG---LGYMHAI-GINKLIMSSSCALYDGTVAAIGEPIDFSYVPGSMSKSGE 196

  Fly   194 RMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPL 258
            :|||:|:|||..:|.|...: :...:.::..:.:||..:   .:|..:.|..:.||...||...:
Worm   197 KMSLFEKLENYRLSMASSRM-QYGQWDKETEIYKKHLGN---DIPHWRDLMPSSSVAFTNSIPYV 257

  Fly   259 TSPRPMSQNMISVGGLHI----LPPKPLPEHIKNYLDNAEHGAIYFSLGSQVRSADMPAEKLQIF 319
            ..||.::|..:.:||:.:    :..:.|.......||...|..: .|.||.|||.|||.:.....
Worm   258 DFPRSITQKTVPIGGISVDMEMIKSQKLSIEWSTVLDERPHNML-ISFGSMVRSMDMPLKWRNGL 321

  Fly   320 LDVFASLKQ-RVLWKFEDDQLPNLP--DNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYH 381
            |:...|... ..:||:|:|.|....  .|:...||:||..:|....:..|:.||||....|..:.
Worm   322 LEAIKSEPNVTFIWKYENDNLEWAKGIQNIYFSKWVPQTALLNDARLTAFMTHGGLGSTNELAFL 386

  Fly   382 AVPVLGMPFYFDQDINIKAGQAAGYA---------IGLDYRTISKDQLKSALHALLKDPKYQANM 437
            ..|.|.:|.:.|||.|  |...|.:.         :| :::||     ||::.::|.:.|||.|.
Worm   387 GKPALMVPVFADQDRN--ANMLARHGGVLVVHKKELG-NFKTI-----KSSIRSILHEEKYQKNA 443

  Fly   438 MKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLT 502
            .|.|.:..::||...:..:.:..:|.:....|.:.:.|..|.:.|..|:|:.|.|      .|..
Worm   444 RKLSELLNNQPLKPKEQVVKYTEFVAKFGPFPQMDSYGRQLGFIQRNLIDIYAAI------SLSY 502

  Fly   503 LYAVSRNYKSFR 514
            |:.:|..|..|:
Worm   503 LFVISLIYFVFK 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	135/518 (26%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	132/503 (26%)
ugt-25	NP_491438.1	egt	1..477	CDD:223071	127/487 (26%)
ugt-25	NP_491438.1	UDPGT	29..530	CDD:278624	137/525 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860