Protein Alignment Ugt49B2 and UGT3A2

DIOPT Version :9

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 153/549 - (27%)
• Similarity: 250/549 - (45%)
• Gaps: 94/549 - (17%)

  Fly    16 GDGARILAPFFLP-------VK---------SHFMMTDAIIRELVKRGHEVT--------FITPL 56
            |....:|..|.||       .|         ||:::.|.:.:.|...||.||        |:..|
Human     3 GQRVLLLVGFLLPGVLLSEAAKILTISTVGGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFMPGL 67

  Fly    57 SLAKENLGPNYREILLPKYDTWADISAMMKTKSALDMID-MSKLTHMRLAQHIGIKSTDFALAHP 120
            |.:..:.....|.:.|.||..:. :....|.:.:..:|. ::...|.|..:    ||.||.|...
Human    68 SDSPASASRYPRILYLQKYCQFG-LKDFKKEEKSYQVISWLAPEDHQREFK----KSFDFFLEET 127

  Fly   121 -------------------EVQELIYAKD-----KKGKFDLLLVEQFHNEGALM---LGYIYEIP 158
                               :....:..||     |...||:::||.|.....|:   ||.    |
Human   128 LGGRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNENFDMVIVETFDYCPFLIAEKLGK----P 188

  Fly   159 AITIATFAYANYFSQVFGFVNPLSYVPNVFLS-CTDRMSLWERLENVVISTAEDVVREVSYYPQQ 222
            .:.|.:.::.   |..||...|||||| ||.| .||.|..|.|::|.::.        .|:..:|
Human   189 FVAILSTSFG---SLEFGLPIPLSYVP-VFRSLLTDHMDFWGRVKNFLMF--------FSFCRRQ 241

  Fly   223 -------DAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPK 280
                   |..|::||:.  ...|.:..|.....:..:||.......||:..|.:.||||...|.|
Human   242 QHMQSTFDNTIKEHFTE--GSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGGLMEKPIK 304

  Fly   281 PLPEHIKNYLDN-AEHGAIYFSLGSQVRSADMPAEKLQIFLDV---FASLKQRVLWKFEDDQLP- 340
            |:|:.::|::.. .:.|.:..:|||.|.:...|    :||.::   ||.|.|.|:||.:....|
Human   305 PVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNP----EIFKEMNNAFAHLPQGVIWKCQCSHWPK 365

  Fly   341 --NLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQA 403
              :|..|||:..||||:|:||||::::|:.|||...:.||:.|.||::|:|.:.||..|:...:|
Human   366 DVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENMVRVEA 430

  Fly   404 AGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGA 468
            ..:.:.:..:.:..:.|...:..:::|.:|::..:.||.|.|..||......:.||::|::..||
Human   431 KKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHVLQTGGA 495

  Fly   469 PHLVAAGVHLPWYQFYLLDVSAIILAITL 497
            .||.......||::.|||||...:|.:||
Human   496 THLKPYVFQQPWHEQYLLDVFVFLLGLTL 524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	153/549 (28%)
		UDPGT	31..497	CDD:278624	145/516 (28%)
UGT3A2	XP_011512290.1	UDPGT	23..518	CDD:278624	145/521 (28%)
		egt	<162..517	CDD:223071	118/376 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150721
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740