DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	564	Identity:	162/564 - (28%)
Similarity:	264/564 - (46%)	Gaps:	91/564 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVCLL---GTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITP------------- 55
            |.:|||   |.|...::|.   :|:. ||:.....::.:|:.:||||..:.|
  Rat    12 LGLCLLLASGFGHAGKLLV---VPMDGSHWFTMQMVVEKLLPKGHEVVVVVPEVSWQLGKPLNFT 73

  Fly    56 -----LSLAKENLGPNYREILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDF 115
                 :|..:|:|...::..          |.:..||:....::.:  ||..  ||..      |
  Rat    74 VKTYSVSHTQEDLNREFKFF----------IDSQWKTQQEGGVLPL--LTSP--AQGF------F 118

  Fly   116 ALAHPEVQELIYAKDKK-------GKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQ 173
            .|.....:.|.  ||||       ..||.:.::.|...|..:..| :.:|::..:...:.:|..:
  Rat   119 ELLFSHCRSLF--KDKKLVEYLKQSSFDAVFLDPFDVCGLTVAKY-FSLPSVVFSRGIFCHYLEE 180

  Fly   174 VFGFVNPLSYVPNVFLSCTDRMSLWERLENVV------------ISTAEDVVREVSYYPQQDAVI 226
            .....:|.||||...|..||.|:..||:.|::            ..||.|:..||...|
  Rat   181 GSQCPSPPSYVPRGILKLTDTMTFKERVWNLLSYMGEHAFCPSFFKTATDIASEVLQTP------ 239

  Fly   227 RKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD 291
                       .|:..|...:||.||.:...|..|||:..|:|.:||::....|||.:..:.|::
  Rat   240 -----------VTMTDLFSPVSVWLLRTDFTLELPRPVMPNVIHIGGINCHQRKPLSKEFEAYVN 293

  Fly   292 -NAEHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQA 355
             :.|||.:.|||||.|  :::|.:|.....:....:.|.|||::...:..||..|..:.|||||.
  Rat   294 ASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQN 356

  Fly   356 DILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQL 420
            |:|.||..:.||.|.|..|:.|.:.:.||::.||.:.||..|.|..:..|..:.|:...::.|.|
  Rat   357 DLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDL 421

  Fly   421 KSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYL 485
            ::||..::.:..|:.|:|:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|||::.
  Rat   422 ENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHS 486

  Fly   486 LDVSAIILAITLLPLLTLYAVSRNY---KSFRGIRAQKKEAKTE 526
            |||...:|||.|..:..:|. |..|   |.|.|....||..|::
  Rat   487 LDVIGFLLAIVLTVVFIVYK-SCAYGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	153/535 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	144/503 (29%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	153/541 (28%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	87/242 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860