Protein Alignment Ugt49B2 and UGT3A1

DIOPT Version :9

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_689617.3
• Gene: UGT3A1 / 133688
• HGNCID: 26625
• Length: 523
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 151/562 - (26%)
• Similarity: 264/562 - (46%)
• Gaps: 88/562 - (15%)

  Fly     7 LLFVCLLGTG----DGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVT-------FITPLSLAK 60
            ||.|..|.:|    :.|:||....|. .||:::.|.:.:.|.:.||.||       |:.|....:
Human     7 LLLVAFLLSGVLLSEAAKILTISTLG-GSHYLLLDRVSQILQEHGHNVTMLHQSGKFLIPDIKEE 70

  Fly    61 EN-------LGP-NYREILLPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFAL 117
            |.       ..| ::::.:...:|::.:        :|||....|:.. ::|.:..|.:.: :.|
Human    71 EKSYQVIRWFSPEDHQKRIKKHFDSYIE--------TALDGRKESEAL-VKLMEIFGTQCS-YLL 125

  Fly   118 AHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYE-IPAITIATFAYANYFSQVFGFVNPL 181
            :..::.:.:    |...:||:.||.|.....|:...:.: ..||...||.     |..||..:||
Human   126 SRKDIMDSL----KNENYDLVFVEAFDFCSFLIAEKLVKPFVAILPTTFG-----SLDFGLPSPL 181

  Fly   182 SYVPNVFLS-CTDRMSLWERLENVVI------------STAEDVVREVSYYPQQDAVIRKHFSSL 233
            |||| ||.| .||.|..|.|::|.::            ||.::.::|  ::|:...
Human   182 SYVP-VFPSLLTDHMDFWGRVKNFLMFFSFSRSQWDMQSTFDNTIKE--HFPEGSR--------- 234

  Fly   234 LPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDN-AEHGA 297
                |.:..|.....:..:||.......||:..|.:.:|||...|.||:|:.:.|::.| .:.|.
Human   235 ----PVLSHLLLKAELWFVNSDFAFDFARPLLPNTVYIGGLMEKPIKPVPQDLDNFIANFGDAGF 295

  Fly   298 IYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLP---NLPDNVKVEKWLPQADILA 359
            :..:.||.: :.....|.|:...:.||.|.|.|:|..:....|   :|..|||:..||||:|:||
Human   296 VLVAFGSML-NTHQSQEVLKKMHNAFAHLPQGVIWTCQSSHWPRDVHLATNVKIVDWLPQSDLLA 359

  Fly   360 HPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSAL 424
            ||::::|:.|||...:.||:.|.||::|:|...||..|:....|..|.:.:....::.|.|...:
Human   360 HPSIRLFVTHGGQNSVMEAIRHGVPMVGLPVNGDQHGNMVRVVAKNYGVSIRLNQVTADTLTLTM 424

  Fly   425 HALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVS 489
            ..:::|.:|::.::.||.|...:||......:.||:::::..||.||.......||::.||:||.
Human   425 KQVIEDKRYKSAVVAASVILHSQPLSPAQRLVGWIDHILQTGGATHLKPYAFQQPWHEQYLIDVF 489

  Fly   490 AIILAITL------LPLLTLYAVSRNYKSFRGIRAQKKEAKT 525
            ..:|.:||      ..||.:.|        |.:|..:|..||
Human   490 VFLLGLTLGTMWLCGKLLGVVA--------RWLRGARKVKKT 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	144/537 (27%)
		UDPGT	31..497	CDD:278624	132/498 (27%)
UGT3A1	NP_689617.3	UDPGT	23..523	CDD:330975	144/544 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150085
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740