DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	154/557 - (27%)
Similarity:	266/557 - (47%)	Gaps:	81/557 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITP---LSLAKENLGPNYR 68
            ||:.|.|:..|.::|.   :|.. ||::....|:..|.:|||::..:.|   |.|.:...   ||
  Rat    15 LFLVLWGSVLGDKLLV---VPQDGSHWLSMKEIVEHLSERGHDIVVLVPEVNLLLGESKY---YR 73

  Fly    69 ----------EILLPKYDTWAD---------ISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTD 114
                      |.|..:|.::.:         ::.:.:.::.:.:|||...:
  Rat    74 RKSFPVPYNLEELRTRYRSFGNNHFAASSPLMAPLREYRNNMIVIDMCFFS-------------- 124

  Fly   115 FALAHPEVQELIYAKD-------KKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANY-- 170
                   .|.|:  ||       ::.:||.|..:.....|.::..|: ::|::    :.:..:
  Rat   125 -------CQSLL--KDSATLSFLRENQFDALFTDPAMPCGVILAEYL-KLPSV----YLFRGFPC 175

  Fly   171 -FSQVFG-FVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSL 233
             ...:.| ..:|:||||..:...:|.|:..:||.|.:.:..|:.:....|...:...     |.|
  Rat   176 SLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIANILENYLYHCLYSKYEILA-----SDL 235

  Fly   234 LPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-NAEHGA 297
            |.|..::..|.|| |:.||........|||:..|||.:||.:......|.:..:.|:: :.|||.
  Rat   236 LKRDVSLPALHQN-SLWLLRYDFVFEYPRPVMPNMIFIGGTNCKKKGNLSQEFEAYVNASGEHGI 299

  Fly   298 IYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPN 362
            :.|||||.|  :::|.:|.....:....:.|.|||::...:..||..|..:.|||||.|:|.||.
  Rat   300 VVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPK 362

  Fly   363 VKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHAL 427
            .:.||.|.|..|:.|.:.:.||::.||.:.||..|.|..:..|..:.|:...::.|.|::||..:
  Rat   363 ARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTV 427

  Fly   428 LKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAII 492
            :.:..|:.|:|:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|||::.|||...:
  Rat   428 INNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFL 492

  Fly   493 LAITLLPLLTLYAVSRNY---KSFRGIRAQKKEAKTE 526
            |||.|..:..:|. |..|   |.|.|....||..|::
  Rat   493 LAIVLTVVFIVYK-SCAYGCRKCFGGKGRVKKSHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	145/528 (27%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	137/499 (27%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	145/530 (27%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	146/537 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860