DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_444445.2	Gene:	Ugt2b37 / 112417	MGIID:	2148239	Length:	530	Species:	Mus musculus

Alignment Length:	531	Identity:	159/531 - (29%)
Similarity:	259/531 - (48%)	Gaps:	69/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHFMMTDAIIRELVKRGHEVTFIT--------------------PLSLAKENLGPNYREIL---- 71
            ||:|....|:.|||:||||||.:.                    |.|:.|::|...:.::|
Mouse    34 SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKFETFPTSVTKDDLENFFIQLLNVWT 98

  Fly    72 --LPKYDTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKDKKGK 134
              |.: ||....|.:|:     :|.|.....::.|.:.:            .....:..|.::.|
Mouse    99 YELSR-DTCLSYSPLMQ-----NMFDELSGYYLSLCKDV------------VSNRQLMTKLQESK 145

  Fly   135 FDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFG-FVNPLSYVPNVFLSCTDRMSLW 198
            ||:||.:.....|.| :..:..||.:....|.......:..| |:.|.||||.:......:|:..
Mouse   146 FDVLLSDPVAFGGEL-IAELLHIPFLYSLRFTAGYRIEKSSGRFLLPPSYVPVILSGLGGQMTFI 209

  Fly   199 ERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRP 263
            ||::|::.....|...::....:.|:    .::..|.|..|:.:......:.|:.|...|..|.|
Mouse   210 ERVKNMICMLYFDFWFQMPNDKKWDS----FYTEYLGRPTTLAETMGQAEMWLIRSNWDLEFPHP 270

  Fly   264 MSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLK 327
            ...|:..|||||..|.||||:.::.|:.:: :||.:.|||||.|  :::..||:.......|.:.
Mouse   271 TLPNVDYVGGLHCKPAKPLPKDMEEYVQSSGDHGVVVFSLGSMV--SNITEEKVNAIAWALAQIP 333

  Fly   328 QRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYF 392
            |:|||||:......|..|.:|.|||||.|:|.||..|.||.|||...:.||:||.:|::|:|.:.
Mouse   334 QKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFITHGGANSVYEAIYHGIPMIGIPLFG 398

  Fly   393 DQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMY 457
            :|..||....|.|.|:.|:.||:|:..:.:||..::::|.|:.|.|..|.|..|:|:..:|.|::
Mouse   399 EQHDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIENPFYKKNAMWLSTIHHDQPMKPLDRAVF 463

  Fly   458 WINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILA-------ITLLPLLTLYAVSRNYKSFRG 515
            |:.:|:.|:.|.||...|.:|.|||::.|||...:||       :|:..||.:|         |.
Mouse   464 WVEFVMRHKNAKHLRPLGHNLTWYQYHSLDVIGFLLACVAATVVLTVKCLLFIY---------RF 519

  Fly   516 IRAQKKEAKTE 526
            ...:||:.|.|
Mouse   520 FVTKKKKMKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	152/505 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	150/500 (30%)
Ugt2b37	NP_444445.2	UDPGT	24..527	CDD:278624	157/526 (30%)
		Glycosyltransferase_GTB_type	42..>174	CDD:299143	33/150 (22%)
		egt	<270..489	CDD:223071	87/220 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840787
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.790