Protein Alignment Ugt49B2 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_001097859.4
• Gene: Ugt49B2 / 42538
• FlyBaseID: FBgn0038886
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 158/524 - (30%)
• Similarity: 267/524 - (50%)
• Gaps: 62/524 - (11%)

  Fly    31 SHFMMTDAIIRELVKRGHEVTF--------------------ITPLSLAKENLGPNYREILLPKY 75
            ||::....|:.||::|.|.||.                    :.|:|..|.|:......:::
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSNIDSLIEHMIM--- 302

  Fly    76 DTWAD-------ISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKDKKG 133
             .|.|       |.|..|        ::.||  :.....|.|:..|..|.:|:    :.|:.:||
Human   303 -LWIDHRPTPLTIWAFYK--------ELGKL--LDTFFQINIQLCDGVLKNPK----LMARLQKG 352

  Fly   134 KFDLLLVEQFHNEG---ALMLGYIYEIPAITIATFAYANYFSQVFGFV-NPLSYVPNVFLSCTDR 194
            .||:|:.:.....|   ||.||    ||.:....|:.|:...:..|.: .|:||||......||:
Human   353 GFDVLVADPVTICGDLVALKLG----IPFMYTLRFSPASTVERHCGKIPAPVSYVPAALSELTDQ 413

  Fly   195 MSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLT 259
            |:..||::|.:..:.:|.:.: ||:.:.::    ::|.:|.|..|:.:......:.|:.:|....
Human   414 MTFGERIKNTISYSLQDYIFQ-SYWGEWNS----YYSKILGRPTTLCETMGKAEIWLIRTYWDFE 473

  Fly   260 SPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVF 323
            .|||...|...|||||..|.||||:.::.::.:: ::|.:.|||||.|:  ::..||..:.....
Human   474 FPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKNGVVVFSLGSMVK--NLTEEKANLIASAL 536

  Fly   324 ASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGM 388
            |.:.|:|||:::..:...|.:|.::..|:||.|:|.||..|.||.|||..|:.||:||.||::|:
Human   537 AQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGV 601

  Fly   389 PFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMD 453
            |.:.||..||...:|.|.|:.::..|::...|.|||..::.:|.|:.|.|:.|||..|:|:..:|
Human   602 PMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLD 666

  Fly   454 TAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIIL-AITLLPLLTLYAVSRNYKSFRGIR 517
            .|::||.:|:.|:||.||..|...|.|:|::.|||...:| .:|....|.:.....:.:.|..|.
Human   667 RAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFLLVCVTTAIFLVIQCCLFSCQKFGKIG 731

  Fly   518 AQKK 521
            .:||
Human   732 KKKK 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	Glycosyltransferase_GTB-type	31..497	CDD:471961	152/498 (31%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	154/512 (30%)