DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt49B2 and Ugt3a1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_997099.2	Gene:	Ugt3a1 / 105887	MGIID:	2146055	Length:	523	Species:	Mus musculus

Alignment Length:	561	Identity:	147/561 - (26%)
Similarity:	256/561 - (45%)	Gaps:	95/561 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITPLSLAKENLGPNYREIL 71
            ||.|.||   :.|:||....|.. ||:::.:.:.:.|...||:|     :.|..|.
Mouse    14 LLEVLLL---EAAKILTISTLSA-SHYILMNRVSQILQGGGHDV-----IKLLYEG--------- 60

  Fly    72 LPKYDTWADISAMMKTKSALDMID------------------MSKLTHMRLAQHIGIKSTDF--- 115
                   .||....|..|:..:|:                  :.:..:.|...|..:|...:
Mouse    61 -------GDIPDFRKENSSYQVINWRLPEDQQKTFENRWHRLIDEYAYGRSKYHTLLKIHQYFAD 118

  Fly   116 ----ALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALM---LG--YIYEIPAITIATFAYANYF 171
                .|:..::.||:    :|..|||:|::.......|:   ||  ::..:|    ..|:|.:
Mouse   119 LCSHLLSRKDIMELL----QKENFDLVLLDSMDLCSFLIVEKLGKRFVSFLP----FQFSYMD-- 173

  Fly   172 SQVFGFVN-PLSYVPNVFLSCTDRMSLWERLENVVI-----STAEDVVREVSYYPQQDAVIRKHF 230
               ||..| ||||.|......||:|..|.|::|:::     ....|:      :.|....:::||
Mouse   174 ---FGLPNAPLSYAPVYGSGLTDQMDFWGRVKNILMFFHFTKKRRDI------FSQYGNTVQEHF 229

  Fly   231 SSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDN-AE 294
            :.  ...|.:..|.....:..:||...|...||:..|.:.||||...|.:|:|:.:::::.. .:
Mouse   230 AE--GSQPVLSDLLLKAELWFVNSDFALDFARPLFPNTVYVGGLLDKPVQPIPQDLEDFISQFGD 292

  Fly   295 HGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLP---NLPDNVKVEKWLPQAD 356
            .|.:..:|||.| |.....|.::.....||.|.|.|||..:....|   :|..|||:..||||.|
Mouse   293 SGFVLVALGSVV-SMIQSKEIIKEMNSAFAHLPQGVLWTCKSSHWPKDVSLAPNVKIMDWLPQID 356

  Fly   357 ILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLK 421
            :||||::::|:.|||:..:.|||:|.||::|:||:.||..|:...:|....:.:..:|:..:...
Mouse   357 LLAHPSIRLFVTHGGMNSVMEAVHHGVPMVGIPFFGDQPENMVRVEAKNLGVSIQLQTLKAESFL 421

  Fly   422 SALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLL 486
            ..:..:::|.:|:...|.:..|.:..||......:.||:::::..||.||.......||::.|:|
Mouse   422 LTMKEVIEDQRYKTAAMASKVIRQSHPLTPAQRLVGWIDHILQTGGAAHLKPYAFQQPWHEQYML 486

  Fly   487 DVSAIILAITL----LPLLTLYAVSRNYKSFRGIRAQKKEA 523
            ||...:|.:||    |.:..|.||:|    :..|..:.|:|
Mouse   487 DVFLFLLGLTLGTLWLSVKVLVAVTR----YLSISRKVKQA 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	140/538 (26%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	128/505 (25%)
Ugt3a1	NP_997099.2	UDPGT	24..488	CDD:278624	128/507 (25%)
Ugt3a1	NP_997099.2	egt	<235..488	CDD:223071	77/253 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840794
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740