DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and Ugt2b38

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_598655.1	Gene:	Ugt2b38 / 100559	MGIID:	2140794	Length:	530	Species:	Mus musculus

Alignment Length:	527	Identity:	157/527 - (29%)
Similarity:	267/527 - (50%)	Gaps:	70/527 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHFMMTDAIIRELVKRGHEVTFIT--------------------PLSLAKENLGPNYREILLPKY 75
            ||:|....|:.|||:||||||.:.                    |.|::|:||    ....:...
Mouse    34 SHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKFETFPTSVSKDNL----ENFFIKFV 94

  Fly    76 DTWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKD-----KKGKF 135
            |.|           ..:|...:.|::..|.|::..:.:|:.|:  ..::::..|:     ::.||
Mouse    95 DVW-----------TYEMPRDTCLSYSPLLQNMIDEFSDYFLS--LCKDVVSNKELMTKLQESKF 146

  Fly   136 DLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVF-------GFVNPLSYVPNVFLSCTD 193
            |:||.:...:.|.| :..:.:||      |.|:..||..:       .|:.|.||||.:......
Mouse   147 DVLLSDPVASCGEL-IAELLQIP------FLYSIRFSPGYQIEKSSGRFLLPPSYVPVILSGLGG 204

  Fly   194 RMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPL 258
            :|:..||::|::.....|...::....:.|:    .:|..|.|..|:.:......:.|:.|...|
Mouse   205 QMTFIERVKNMICRLYFDFWFQMFNDKKWDS----FYSEYLGRPTTLAETMGKAEMWLIRSNWDL 265

  Fly   259 TSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDV 322
            ..|.|...|:..|||||..|.||||:.::.::.:: :||.:.|||||.|  ::|..||.......
Mouse   266 EFPHPTLPNVDYVGGLHCKPAKPLPKDMEEFVQSSGDHGVVVFSLGSMV--SNMTEEKANTIAWA 328

  Fly   323 FASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLG 387
            .|.:.|:|||||:......|..|.:|.|||||.|:|.||..|.|:.|||..|:.|.:||.:|::|
Mouse   329 LAQIPQKVLWKFDGKTPATLGHNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEVIYHGIPMIG 393

  Fly   388 MPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAM 452
            :|.:.:|..||....|.|.|:.|:.||:|:..:.:||..::.:|.|:.|.:..|.|..|:|...:
Mouse   394 IPLFGEQHDNIAHMVAKGAAVTLNIRTMSRSDVLNALEEVIDNPFYKKNAIWLSTIHHDQPTKPL 458

  Fly   453 DTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIIL---AITLLPLLTLYAVSRNYKSFR 514
            |.|::|:.:|:.|:.|.||.:.|.:|.|:|::.|||...:|   |:|:  :||:..:...|:.|
Mouse   459 DRAVFWVEFVMRHKRAKHLRSLGHNLTWHQYHFLDVIGFLLSCVAVTI--VLTVKCLLFIYRFF- 520

  Fly   515 GIRAQKK 521
             ::.:||
Mouse   521 -VKKEKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	151/506 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	150/501 (30%)
Ugt2b38	NP_598655.1	egt	8..506	CDD:223071	150/501 (30%)
Ugt2b38	NP_598655.1	UDPGT	24..526	CDD:278624	155/525 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840784
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790