DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt5b2

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001170970.2	Gene:	ugt5b2 / 100415799	ZFINID:	ZDB-GENE-100406-4	Length:	531	Species:	Danio rerio

Alignment Length:	502	Identity:	144/502 - (28%)
Similarity:	253/502 - (50%)	Gaps:	43/502 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHFMMTDAIIRELVKRGHEVTFI-TPLSLAKENLGPNYREILLPKYDTWADISAMMKTKSALDMI 94
            ||::..:.::..|..:||:||.: |..|...:...|:|..|.|.....:        .|..|:..
Zfish    37 SHWVNMNILVEALSAKGHDVTVMRTASSCYIKEFSPHYTSINLKSKGGY--------NKEVLEQF 93

  Fly    95 ---------DMSKLTHMRLAQHIGIKSTDFALAHPEV-------QELIYAKDKKGKFDLLLVEQF 143
                     |.|...|::|...:.........|..|:       |:|:.:. |..|:||:|.:.
Zfish    94 ASRIMHILRDGSTWGHLKLQADMWQSFLKIFEAEREMIVNMIEDQQLMQSL-KDAKYDLILTDP- 156

  Fly   144 HNEGALMLGYIYEIPAITIATFAYANYFSQVFGFV-NPLSYVPNVFLSCTDRMSLWERLENVVIS 207
            :..|.::||:..::|  .:....:|.|....|... :||||||...|..:||||..:|:.|||:.
Zfish   157 NMFGGVILGHYLKLP--MVYNVRWAGYNEAHFSIAPSPLSYVPMPSLELSDRMSFLQRVYNVVMY 219

  Fly   208 TAEDVVREVSYYPQQDAVIRKHF---SSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMI 269
            ...::...:...|..||:..:..   :|.|       .|.|...:.|.........|||...|:|
Zfish   220 IFIEIGAALVISPINDALAERFIGPGTSFL-------SLVQGADLWLHRVDFVFEYPRPTMPNVI 277

  Fly   270 SVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWK 333
            .:.|....|.||||:.:::::.:: :||.|..|||:.:..  :|.:..:...:.||.|.|:::|:
Zfish   278 YMAGFQCKPSKPLPQDLEDFVQSSGDHGVIIMSLGTLIDK--LPDDVAEAIAEAFAELPQKIIWR 340

  Fly   334 FEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINI 398
            ::..:...|.:|..:..|:||.|:|.||..:.|:||||..|:|||:||.||::|....|||..|:
Zfish   341 YKGKRPSALGNNTLIMDWMPQNDLLGHPKTRAFVAHGGTNGIQEAIYHGVPIIGFGLIFDQPDNL 405

  Fly   399 KAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVV 463
            ...:..|.|..:|:.|::|:...:.:..:|.||.|:.||.:.||:.:|.|:..:|.|::||.:|:
Zfish   406 SKMRVRGAAKNVDFATMNKESFLTTVKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVM 470

  Fly   464 EHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLTLYAVSRNY 510
            .|:||.||......:|||.::.:||..::::...|.:|::|||.|.:
Zfish   471 RHKGAAHLRTESYKMPWYSYHSVDVILVLISAVSLIILSIYAVIRYF 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	139/492 (28%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	138/487 (28%)
ugt5b2	NP_001170970.2	egt	12..501	CDD:223071	138/484 (29%)
ugt5b2	NP_001170970.2	UDPGT	27..525	CDD:278624	144/502 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585216
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790