DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt5d1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001170967.1	Gene:	ugt5d1 / 100415794	ZFINID:	ZDB-GENE-091118-36	Length:	532	Species:	Danio rerio

Alignment Length:	537	Identity:	155/537 - (28%)
Similarity:	253/537 - (47%)	Gaps:	64/537 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LFMKLLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITPLS--------- 57
            ||:.|....|  :..|.:||   ..||. ||::....:|.||..|||.:|.|.|.|
Zfish    14 LFLALSAFTL--SCSGGKIL---LYPVDGSHWVNMKVLIEELHSRGHSITVIRPKSSWYITEKSP 73

  Fly    58 -----LAKENLG--PNYREILLPKYDTWADI-----SAMMKTKSALDMIDMSKLTHMRLAQHIGI 110
                 ..::|:.  .|:.|..|.|.   .:|     |.:...|...|:..|....|....:.:.|
Zfish    74 LYTSITIQDNVNDFENFFEDYLSKA---MEIERGEGSGLAFLKLQYDLFSMLSTAHEIACKMVSI 135

  Fly   111 KSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIAT--------FAY 167
            ...|         :::..|.:..::||:|.:. ...|.:.|.:..::|.:....        ||.
Zfish   136 ILED---------KMLVKKLQDEQYDLMLTDP-AIAGGVFLAHYLKLPLVLNVRWITSGEGHFAI 190

  Fly   168 ANYFSQVFGFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSS 232
            |         .:|:||:|......||:|...:|::||:..|...:.......|..|.:|.|:
Zfish   191 A---------PSPMSYIPLPGSGHTDKMGFAQRVKNVLFKTFTFLQNRFVVGPHYDILIDKY--- 243

  Fly   233 LLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHG 296
             |.....:..|.|...:.|:.:......|||...|::.:||....|.||||..::.:..:: |||
Zfish   244 -LDYKTDIVGLIQAADIWLMRADFVFEFPRPTMPNIVYMGGFRCKPSKPLPADLEAFAQSSGEHG 307

  Fly   297 AIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHP 361
            .|..|||:.|:|  :||:........||.|.|:|:|:...|:..|:.:|..:..|:||.|:|.|.
Zfish   308 FIIMSLGTLVKS--LPADMANAIAAAFARLPQKVIWRHLGDRPSNVGNNTLIVDWMPQNDLLGHS 370

  Fly   362 NVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHA 426
            .:|.|:||||..|:|||::|.|||||:|.:|||..|:...|..|....|....::.:..:.||..
Zfish   371 KIKAFVAHGGTNGVQEAIFHGVPVLGVPLFFDQFDNLIRVQGKGAGKILKLSELNAEAFEQALRE 435

  Fly   427 LLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAI 491
            .|.|..|:.||...|.:.||:|:..:|||::||.:|:.|:||.||.:....:|||.::.:||..:
Zfish   436 SLNDGSYKRNMQTLSTLHRDQPMRPLDTAIFWIEHVIRHKGATHLRSEFYKMPWYSYHSVDVFLV 500

  Fly   492 ILAITLLPLLTLYAVSR 508
            :..:..:.:|:..||.|
Zfish   501 LFIVAAVCMLSTIAVIR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	151/529 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	142/495 (29%)
ugt5d1	NP_001170967.1	UDPGT	28..527	CDD:278624	150/521 (29%)
ugt5d1	NP_001170967.1	egt	<267..506	CDD:223071	88/240 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585288
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790