DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	565	Identity:	169/565 - (29%)
Similarity:	276/565 - (48%)	Gaps:	90/565 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILFMKLLFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFI--TPLSLAKEN 62
            ||:|..|   |     ||.:||.   .|:: ||::..|.:|:.|..:||.|..|  |.....|||
Zfish    18 MIIFGSL---C-----DGGKILV---APLEGSHWVNMDILIKALHGQGHTVDVIRNTNSWFVKEN 71

  Fly    63 LGPNYREILLPKYDTWADISAM-------MKTKSALD--------------MIDMSKLTH----- 101
             ...|..|.:|      |...|       :.||. :|              .:|:||..:
Zfish    72 -STYYNSITIP------DSKGMDEEFVEDVLTKK-IDYERGKGSWLGGVQLFLDVSKAVYESHKL 128

  Fly   102 -MRLAQHIGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIA-- 163
             .||..:|.           |.::::.|..:| |:||:|.:.....| ::|.:..::|.:...
Zfish   129 VCRLITNIF-----------ESEDILKALQEK-KYDLMLTDPGWGTG-IILAHKLKLPMVYNVRW 180

  Fly   164 TFAYANYFSQVFGFVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRK 228
            |.....:|...   .:|:||:|......||:||.::|:.||......|........||..|:..|
Zfish   181 TTPGEGHFDIA---PSPMSYIPLTGSGNTDKMSFFQRVINVFYYLLLDFQCSRFNVPQYQALCDK 242

  Fly   229 HFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA 293
            :|.   |.|...|.| |...:.|:........|||...|:|..||....|.||||..:::::.::
Zfish   243 YFD---PPVDFYKLL-QGADLWLMRVDFVFEFPRPTMPNIIYTGGFQCTPTKPLPHDLEDFMQSS 303

  Fly   294 -EHGAIYFSLGSQVR------SADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKW 351
             :||.|..||||.:.      |:::.|        .||.|.|:|:|::...:...|.:|..:..|
Zfish   304 GDHGVIVMSLGSFISVLPDYVSSEIAA--------AFARLPQKVIWRYTGKKPSTLGNNTLLVDW 360

  Fly   352 LPQADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTIS 416
            :||.|:|.||..|:||||||..|:|||:||.|||:|:||:|||..|:...||.|.|..:....:.
Zfish   361 MPQKDLLGHPKTKLFIAHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKIVSLAELG 425

  Fly   417 KDQLKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWY 481
            ::.|.:|:..::.:|.|:.||.|.|.:.||:|:..:|:|::||.:|:.|:||.||......:|||
Zfish   426 ENSLHAAIQEVINEPSYRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRTESYKMPWY 490

  Fly   482 QFYLLDVSAIILAITLLPLLTLYAVSRNYKSFRGIRAQKKEAKTE 526
            .::.:|||..::|:.|:.:.:::...|    :..|:...::.|||
Zfish   491 SYHSVDVSVTLIAVVLIFIYSMFVTVR----YLCIKCCSRKRKTE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	164/539 (30%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	153/503 (30%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	159/544 (29%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	91/247 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585279
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.790