DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	517	Identity:	150/517 - (29%)
Similarity:	264/517 - (51%)	Gaps:	73/517 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SHFMMTDAIIRELVKRGHEVT--------FITPLS-------------LAKENLGPNYREI--LL 72
            ||::..:.::..|..:||.:|        :|...|             |:::.:||....:  :|
Zfish    37 SHWVNMNVLVEALHAKGHNITVMRMADSWYIKEFSPHYTSVNLKSSGGLSEDFIGPFVSRLMNIL 101

  Fly    73 PKYDTWADISAMMKT-KSALDMIDMSK--LTHMRLAQHIGIKSTDFALAHPEVQELIYAKDKKGK 134
            .:..||..:...::. :::|.||::.:  :|:|                 .|.|:|:.:. ||.|
Zfish   102 REGSTWGRLKLEIEMWQTSLKMIEIEREMITNM-----------------IEDQQLMQSL-KKAK 148

  Fly   135 FDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANYFSQVFG---FV---NPLSYVPNVFLSCTD 193
            |||:|.:. ...|.:|||:..::|.:       .|....:||   |.   :||||||...|...|
Zfish   149 FDLILTDP-AMYGGVMLGHYLKLPIV-------YNVRWTIFGEGHFAIAPSPLSYVPVPMLEIPD 205

  Fly   194 RMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRV--PTVK--QLEQNISVILLNS 254
            |||..||::|||:.    ::.|.    |...:|...:::|..|.  |.|.  .|.|...:.|..:
Zfish   206 RMSFLERVKNVVMY----IITET----QIAFLIAPTYNALCERFIGPEVNFGNLVQEADLWLHRA 262

  Fly   255 YMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGAIYFSLGSQVRSADMPAEKLQI 318
            ......|||...|::.:.|....|.||||:.:::::.:: :||.|..|||:.:  ..:|.:..:.
Zfish   263 DFVFEYPRPTMPNIVYMAGFQCKPSKPLPQDLEDFVQSSGDHGVIVMSLGTLI--GQLPDDVAEA 325

  Fly   319 FLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPNVKVFIAHGGLFGMQEAVYHAV 383
            ..:.||.|.|:::|:::..:...|.:|..|..|:||.|:|.||..:.|:||||..|:|||:||.|
Zfish   326 IAEAFAELPQKIIWRYKGKRPSALGNNTLVMDWMPQNDLLGHPKTRAFVAHGGTNGVQEAIYHGV 390

  Fly   384 PVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSALHALLKDPKYQANMMKASRIFRDRP 448
            |::|....|||..|:...:..|.|..:|:.|:.|:.....:..:|.||.|:.||.:.||:.:|.|
Zfish   391 PIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTVKEVLYDPSYRENMQRLSRLHKDVP 455

  Fly   449 LGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAIILAITLLPLLTLYAVSRNY 510
            :..:|.|::||.:|:.|:||.||......:|||.::.:||..::::...|.:|::|||.|.:
Zfish   456 VKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVLISAVSLIILSIYAVIRYF 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	145/507 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	144/502 (29%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	150/517 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585210
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790