DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	561	Identity:	155/561 - (27%)
Similarity:	270/561 - (48%)	Gaps:	76/561 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILFMKLLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITP----LSLAKE 61
            ::.|:.||.|  ...|....||.  :....||::....::..|:.|||.||.:.|    ...|||
Zfish     4 VVCFLSLLTV--FSAGQCGNILV--WYTEGSHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAKE 64

  Fly    62 NLGPNYREILLPKYDTWADISAMMKTKSALDM--------------IDMSKLTHMRL------AQ 106
            :...:|:...:              :|||.||              :|.|....:::      :|
Zfish    65 SDRFSYQHFSV--------------SKSAQDMQDFFDELMRFSVFEMDNSSFLEIQMKFFNLGSQ 115

  Fly   107 H--IGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYAN 169
            |  :.:...|..|..||:.:    |.||||||::|.:..:....::...: .:|.:....|:.|:
Zfish   116 HQDMSLSYCDGILKSPELMD----KLKKGKFDVVLSDPMYPCSDIVAEEL-NVPLVYTFRFSVAH 175

  Fly   170 YFSQVFGFV-NPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIR------ 227
            ...::.|.: .|.||||......||:||..||:.|::            :|..||.:.|
Zfish   176 AAERMCGQIPAPPSYVPGAMSKLTDKMSFTERIFNML------------FYLSQDTLSRLIWRRF 228

  Fly   228 -KHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD 291
             .:::....|..:..::.....:.|:.:|.....|||...|...:||||..|.||||:.::.::.
Zfish   229 DNYYTEYFGRSTSYCEMMGKADIWLIRTYWDFEFPRPFVPNFKYIGGLHCTPAKPLPKDMEEFVQ 293

  Fly   292 NA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQA 355
            :: :.|.:.|:|||.:..  :|.|.........|.:.|:|||::..::...|.:|.::.||:||.
Zfish   294 SSGDDGIVVFTLGSMIDK--VPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRIYKWIPQN 356

  Fly   356 DILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLD-YRTISKDQ 419
            |:|.||..:.||.|||..|:.||:||.||::|:|.:.||..|:........|:.:| .:::...:
Zfish   357 DLLGHPKTRAFITHGGTNGVYEAIYHGVPMVGIPLFGDQPDNMVHMTTRAAAVVVDSIKSMQPQE 421

  Fly   420 LKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFY 484
            |...|:.::.||.|:.|.|:.|||..|||:..:|.:::||.:|:.::||.||.....:|.|||::
Zfish   422 LVDKLNTVINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYH 486

  Fly   485 LLDVSAIILAITLLPLLTLYAVSRNY---KSFRGIRAQKKE 522
            .|||.|.:..:..|.|...:.:::.:   ..||..|..|||
Zfish   487 CLDVFAFLTTVLTLVLYICFKMAKFFIMRCCFRSKRKSKKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	149/536 (28%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	140/501 (28%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	146/537 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860