DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt2b3

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001170812.2	Gene:	ugt2b3 / 100384898	ZFINID:	ZDB-GENE-100402-2	Length:	527	Species:	Danio rerio

Alignment Length:	554	Identity:	153/554 - (27%)
Similarity:	267/554 - (48%)	Gaps:	62/554 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILFMKLLFVCLLGTGDGARILAPFFLPVKSHFMMTDAIIRELVKRGHEVTFITP----LSLAKE 61
            ::.|:.||.|  ...|....||.  :....||::....::..|:.|||.||.:.|    ...|||
Zfish     4 VVCFLSLLTV--FSAGQCGNILV--WHTEGSHWINLKIVLDTLLDRGHNVTVLMPDGALFMKAKE 64

  Fly    62 NLGPNYREILLPKYDTWADISAMMKTKSALDMID-MSKLTHMRL--------------------- 104
            :...:|:...:              :.||.||.| :.:|.|..:
Zfish    65 SDRFSYQNFSV--------------STSAQDMQDFLDELLHFSVFEMEQLNLLQIQMKFFDLGSR 115

  Fly   105 AQHIGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYAN 169
            .|.:|:...|..|..||:.:    |.|.||||:||.:..: ..:.::..:..:|.:....|:.|:
Zfish   116 HQDMGLSYCDGILKSPELMD----KLKTGKFDVLLSDPMY-PCSDIVAEVLNVPLVFTLRFSIAH 175

  Fly   170 YFSQVFGFV-NPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSL 233
            ...::.|.: .|.||||......||:||..||:.|.:...:.|....:::     .....:::..
Zfish   176 TMERICGQIPAPPSYVPGAMSKLTDKMSFTERIFNTLFYLSMDTFSIIAW-----KKFDNYYTEY 235

  Fly   234 LPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLDNA-EHGA 297
            ..|..:..::.....:.|:.:|.....|||...|...:||||..|.||||:.::.::.:: :.|.
Zfish   236 FGRPTSYCEMMGRADIWLIRTYWDFEFPRPFVPNFKYIGGLHCTPAKPLPKDMEEFVQSSGDDGI 300

  Fly   298 IYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADILAHPN 362
            :.|:|||.:..  :|.|.........|.:.|:|||::..::...|.:|.::.||:||.|:|.||.
Zfish   301 VVFTLGSMIDK--VPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRIYKWMPQNDLLGHPK 363

  Fly   363 VKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLD-YRTISKDQLKSALHA 426
            .:.||.|||..|:.||:||.||::|:|.:.||..|:......|.|:.:| .:::...:|...|:.
Zfish   364 TRAFITHGGTNGIYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELVDKLNT 428

  Fly   427 LLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLDVSAI 491
            ::.||.|:.|.|:.|||..|||:..:|.:::||.:|:.::||.||.....:|.|||::.|||.|.
Zfish   429 VINDPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVFAF 493

  Fly   492 ILAITLLPLLTLYAVSRNY---KSFRGIRAQKKE 522
            :..:..|.|...:.:::.:   ..||..|..|||
Zfish   494 LTTVLTLVLYICFKMAKFFIMRCCFRSKRKSKKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	147/529 (28%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	138/494 (28%)
ugt2b3	NP_001170812.2	UDPGT	20..523	CDD:278624	144/530 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585264
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790