DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bap and NANOG

DIOPT Version :9

Sequence 1:	NP_732637.1	Gene:	bap / 42537	FlyBaseID:	FBgn0004862	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_079141.2	Gene:	NANOG / 79923	HGNCID:	20857	Length:	305	Species:	Homo sapiens

Alignment Length:	244	Identity:	62/244 - (25%)
Similarity:	94/244 - (38%)	Gaps:	67/244 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PLCCRDLGLYKLTQPKEIQPS---ARQPSNY--LQYYAAAMDNNNHHHQATGTSNSSAADYMQRK 126
            |.|.:.|..::.:..||..|.   .....||  ||..:|.|.     |..|.:...|:.|.:.:
Human     5 PACPQSLPCFEASDCKESSPMPVICGPEENYPSLQMSSAEMP-----HTETVSPLPSSMDLLIQ- 63

  Fly   127 LAYFGSTLAAPLDMRRCTSNDSDCDSPPPLSSSPSESPLSHDGSGLS-------RKKRSRAAFSH 184
                                    |||...:|...:.|.|.:.|...       :|:::|..||.
Human    64 ------------------------DSPDSSTSPKGKQPTSAEKSVAKKEDKVPVKKQKTRTVFSS 104

  Fly   185 AQVFELERRFAQQRYLSGPERSEMAKSLRLTETQVKIWFQNRRYKTKRKQIQQHEAALLGASKRV 249
            .|:..|..||.:|:|||..:..|::..|.|:..|||.||||:|.|:||.|.........|.:::.
Human   105 TQLCVLNDRFQRQKYLSLQQMQELSNILNLSYKQVKTWFQNQRMKSKRWQKNNWPKNSNGVTQKA 169

  Fly   250 PVQVLVREDGSTTYAHMAAPGAGHGLDPALINIYRHQ--LQLAYGGLPL 296
                     .:.||             |:|.:.| ||  |....|.||:
Human   170 ---------SAPTY-------------PSLYSSY-HQGCLVNPTGNLPM 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bap	NP_732637.1	Homeobox	178..231	CDD:278475	23/52 (44%)
NANOG	NP_079141.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96		23/120 (19%)
		COG5576	74..191	CDD:227863	39/139 (28%)
		HOX	95..151	CDD:197696	24/55 (44%)
		Required for DNA-binding. /evidence=ECO:0000269\|PubMed:25825768	122..151		12/28 (43%)
		8 X repeats starting with a Trp in each unit	196..240		62/244 (25%)
		Sufficient for transactivation activity. /evidence=ECO:0000250	196..240		62/244 (25%)
		Sufficient for strong transactivation activity. /evidence=ECO:0000250	241..305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910