DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bap and PITX1

DIOPT Version :9

Sequence 1:	NP_732637.1	Gene:	bap / 42537	FlyBaseID:	FBgn0004862	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_002644.4	Gene:	PITX1 / 5307	HGNCID:	9004	Length:	314	Species:	Homo sapiens

Alignment Length:	259	Identity:	73/259 - (28%)
Similarity:	102/259 - (39%)	Gaps:	56/259 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 LAAPLDMR----RCTSNDSDCDSP------PPLSSSPSESPLSHDGSG-------LSRKKRSRAA 181
            ||.|.|.|    ...|..||.:.|      .|  ..|.:|.....|.|       ..:::|.|..
Human    33 LARPADPREPLENSASESSDTELPEKERGGEP--KGPEDSGAGGTGCGGADDPAKKKKQRRQRTH 95

  Fly   182 FSHAQVFELERRFAQQRYLSGPERSEMAKSLRLTETQVKIWFQNRRYK-TKRKQIQQHEAALLGA 245
            |:..|:.|||..|.:.||.....|.|:|....|||.:|::||:|||.| .||::.||.:....|.
Human    96 FTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGY 160

  Fly   246 SKRVPVQVLVREDGSTTYAHMAAPGAGHGLDPALINIYRHQLQLAYGGLPLPQMQMPFPYFYPQH 310
            ..:....|...||   .||      ||          |.:....|....|.|.....|.:|
Human   161 VPQFSGLVQPYED---VYA------AG----------YSYNNWAAKSLAPAPLSTKSFTFF---- 202

  Fly   311 KVPQPIPPPTQSSSFVTASSASSSPVPIPI-PGAVRPQRTPCPS-PNGQMMSVES-GAESVHSA 371
               ..:.|.:..|.|...||.||..:|..: ||||       |. ||..:.::.: ...|::||
Human   203 ---NSMSPLSSQSMFSAPSSISSMTMPSSMGPGAV-------PGMPNSGLNNINNLTGSSLNSA 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bap	NP_732637.1	Homeobox	178..231	CDD:278475	22/53 (42%)
PITX1	NP_002644.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103		18/71 (25%)
		COG5576	36..>146	CDD:227863	35/111 (32%)
		Homeobox	93..146	CDD:395001	22/52 (42%)
		Interaction with PIT-1. /evidence=ECO:0000250	147..279		35/143 (24%)
		OAR	276..293	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	280..293
		Nuclear localization signal. /evidence=ECO:0000255	286..290
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910