DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bap and PRRX2

DIOPT Version :9

Sequence 1:	NP_732637.1	Gene:	bap / 42537	FlyBaseID:	FBgn0004862	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_057391.1	Gene:	PRRX2 / 51450	HGNCID:	21338	Length:	253	Species:	Homo sapiens

Alignment Length:	294	Identity:	68/294 - (23%)
Similarity:	100/294 - (34%)	Gaps:	128/294 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 SARQPSNYLQYYAAAMDNNNHHHQATGTSNSSAADYMQRKLAYFGSTLAAPLDMRRCTSNDSDCD 151
            :||:||.                   |:|.|.||                        ..|.:|.
Human    69 AAREPSG-------------------GSSGSEAA------------------------PQDGECP 90

  Fly   152 SPPPLSSSPSESPLSHDGSGLSRKK---RSRAAFSHAQVFELERRFAQQRYLSGPERSEMAKSLR 213
            ||             ..||...|||   |:|..|:.:|:..|||.|.:..|.....|.|:|:.:.
Human    91 SP-------------GRGSAAKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVN 142

  Fly   214 LTETQVKIWFQNRRYKTKRKQ---IQQHEAALLGASKRVPVQVLVREDGSTTYAHMAAPGAGHGL 275
            |:|.:|::||||||.|.:|.:   :....|:||                 .:|:..||
Human   143 LSEARVQVWFQNRRAKFRRNERAMLASRSASLL-----------------KSYSQEAA------- 183

  Fly   276 DPALINIYRHQLQLAYGGLPLPQMQMPFPYFYPQHKVPQPIPP-PTQSSSFVTASSASS--SPVP 337
                                                :.||:.| ||..|....:.:|||  |.||
Human   184 ------------------------------------IEQPVAPRPTALSPDYLSWTASSPYSTVP 212

  Fly   338 IPIPGAVRPQRTPCPSPNGQMMSVESGAE--SVH 369
            ...||:..| .||..:....:.|:...|:  |:|
Human   213 PYSPGSSGP-ATPGVNMANSIASLRLKAKEFSLH 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bap	NP_732637.1	Homeobox	178..231	CDD:278475	21/52 (40%)
PRRX2	NP_057391.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..113		21/99 (21%)
		Homeobox	109..161	CDD:395001	20/51 (39%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	230..243		2/12 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910