DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bap and PAX4

DIOPT Version :9

Sequence 1:	NP_732637.1	Gene:	bap / 42537	FlyBaseID:	FBgn0004862	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001353039.1	Gene:	PAX4 / 5078	HGNCID:	8618	Length:	351	Species:	Homo sapiens

Alignment Length:	251	Identity:	63/251 - (25%)
Similarity:	98/251 - (39%)	Gaps:	75/251 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 CTSNDSDCDSPPPLSS--SPSESPL-SHDGSGLSRKKRSRAAFSHAQVFELERRFAQQRYLSGPE 204
            ||...|.....|.:.:  |.||:|. :|.|:|    .|:|..||.:|...||:.|.:.:|.....
Human   139 CTRLRSPAVLAPAVLTPHSGSETPRGTHPGTG----HRNRTIFSPSQAEALEKEFQRGQYPDSVA 199

  Fly   205 RSEMAKSLRLTETQVKIWFQNRRYKTKRKQIQQHEAALLGASKRVPVQVLVREDGSTTYAHMAAP 269
            |.::|.:..|.|..|::||.|||.|.:|::..:.|                          |..|
Human   200 RGKLATATSLPEDTVRVWFSNRRAKWRRQEKLKWE--------------------------MQLP 238

  Fly   270 GAGHGLD-----PALINIYRHQLQLAYGGLP---LPQMQMPFPYFYPQHKVPQPIPPPTQSSSFV 326
            ||..||.     |.:|:     .|.:.|.:|   ||.:              :|:.|......:.
Human   239 GASQGLTVPRVAPGIIS-----AQQSPGSVPTAALPAL--------------EPLGPSCYQLCWA 284

  Fly   327 TASSASSSPVP-----IPIPGAVRPQRT---------PCPSPNGQMMSVESGAESV 368
            ||.....|..|     .|..|.:.||..         ||||.:..:.|: ||::::
Human   285 TAPERCLSDTPPKACLKPCWGHLPPQPNSLDSGLLCLPCPSSHCHLASL-SGSQAL 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bap	NP_732637.1	Homeobox	178..231	CDD:278475	19/52 (37%)
PAX4	NP_001353039.1	PAX	5..129	CDD:128645
PAX4	NP_001353039.1	Homeobox	174..226	CDD:306543	19/51 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910