DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bap and PAX3

DIOPT Version :9

Sequence 1:	NP_732637.1	Gene:	bap / 42537	FlyBaseID:	FBgn0004862	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_852124.1	Gene:	PAX3 / 5077	HGNCID:	8617	Length:	505	Species:	Homo sapiens

Alignment Length:	256	Identity:	71/256 - (27%)
Similarity:	111/256 - (43%)	Gaps:	55/256 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 AAMDNNNHHHQATGTSNSSAADYMQRKLAYFGSTLAAPLDMRRCTSNDSDCDSPPPLSSSPSE-- 162
            |..|.|      |..|.||.:..::.|   ||.......|:.|..:.:|:..:...:....||
Human   141 AVCDRN------TVPSVSSISRILRSK---FGKGEEEEADLERKEAEESEKKAKHSIDGILSERA 196

  Fly   163 -SPLSHDGSGLS---------RKKRSRAAFSHAQVFELERRFAQQRYLSGPERSEMAKSLRLTET 217
             :|.|.:||.:.         :::|||..|:..|:.||||.|.:..|.....|.|:|:..:|||.
Human   197 SAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEA 261

  Fly   218 QVKIWFQNRRYKTKRKQIQQHEAALLGASKRVPVQVLVREDGSTTYAHMAAPGAGHGLDP-ALIN 281
            :|::||.|||.:. |||        .||::.:....|:             ||   |..| |:..
Human   262 RVQVWFSNRRARW-RKQ--------AGANQLMAFNHLI-------------PG---GFPPTAMPT 301

  Fly   282 IYRHQL-QLAYGGLPLPQMQMPFPYFYPQHKV--PQPIPPPTQSSSFVTASSASSSPVPIP 339
            :..:|| :.:|....:||....     |...|  |||:||.|...|.:.::..|||...:|
Human   302 LPTYQLSETSYQPTSIPQAVSD-----PSSTVHRPQPLPPSTVHQSTIPSNPDSSSAYCLP 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bap	NP_732637.1	Homeobox	178..231	CDD:278475	22/52 (42%)
PAX3	NP_852124.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PAX	34..159	CDD:128645	7/23 (30%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	37..93
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	113..161		7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..228		13/62 (21%)
		Homeobox	222..276	CDD:395001	22/54 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..351		12/46 (26%)
		Pax7	347..391	CDD:403540	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910