DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bap and OTX1

DIOPT Version :9

Sequence 1:	NP_732637.1	Gene:	bap / 42537	FlyBaseID:	FBgn0004862	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001186699.1	Gene:	OTX1 / 5013	HGNCID:	8521	Length:	354	Species:	Homo sapiens

Alignment Length:	236	Identity:	55/236 - (23%)
Similarity:	88/236 - (37%)	Gaps:	60/236 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 ESPLSHDGSGLS------------------RKKRSRAAFSHAQVFELERRFAQQRYLSGPERSEM 208
            :.|...:|.||:                  :::|.|..|:.:|:..||..||:.||.....|.|:
Human     7 QPPYGMNGLGLAGPAMDLLHPSVGYPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEV 71

  Fly   209 AKSLRLTETQVKIWFQNRRYKTKRKQIQQHEAALLGASKR-VPVQVLVREDGSTTYAHMAAP--- 269
            |..:.|.|::|::||:|||.|.:::|..........|.|: .||:   ...||.:......|
Human    72 ALKINLPESRVQVWFKNRRAKCRQQQQSGSGTKSRPAKKKSSPVR---ESSGSESSGQFTPPAVS 133

  Fly   270 --------GAGHGLDPALINIYRHQLQLAYGGLPLPQMQMPFPYFYPQHKVPQPIPPPTQSSSFV 326
                    .:....:||.      ......||.|:              .....:..|..||.:.
Human   134 SSASSSSSASSSSANPAA------AAAAGLGGNPV--------------AAASSLSTPAASSIWS 178

  Fly   327 TAS-SASSSPVPIPIPGAV-RPQRTPCPSPNGQMMSVESGA 365
            .|| |..|:|..:.:|..: .|..|.|     ...||.:||
Human   179 PASISPGSAPASVSVPEPLAAPSNTSC-----MQRSVAAGA 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bap	NP_732637.1	Homeobox	178..231	CDD:278475	21/52 (40%)
OTX1	NP_001186699.1	Homeobox	42..95	CDD:395001	21/52 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..146		9/57 (16%)
		TF_Otx	180..274	CDD:397546	13/40 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910