Protein Alignment bap and NKX2-2

DIOPT Version :10

• Sequence 1: NP_732637.1
• Gene: bap / 42537
• FlyBaseID: FBgn0004862
• Length: 382
• Species: Drosophila melanogaster
• Sequence 2: NP_002500.1
• Gene: NKX2-2 / 4821
• HGNCID: 7835
• Length: 273
• Species: Homo sapiens
• Alignment Length: 317
• Identity: 104/317 - (32%)
• Similarity: 134/317 - (42%)
• Gaps: 72/317 - (22%)

  Fly    19 SLT---TPFSINDILTRSNPETR-RMSSVDSEPEPEKLKPSSDRERSISKSPPLCCRDL-GLYKL 78
            |||   |.||:.|||  ..|:|. ...||...||.|...|...:     ::.||....| .:..|
Human     2 SLTNTKTGFSVKDIL--DLPDTNDEEGSVAEGPEEENEGPEPAK-----RAGPLGQGALDAVQSL 59

  Fly    79 TQPKEIQPSARQPSNYLQYYAAAMDNNNHHHQATGTSNSSAADYMQRKLAYFGSTLAAPLDMRRC 143
            ........|:..|  |.::.|                   :.:.:|..|  .|....||
Human    60 PLKNPFYDSSDNP--YTRWLA-------------------STEGLQYSL--HGLAAGAP------ 95

  Fly   144 TSNDSDCDSPPPLSSSPSESPLSHD------GSGLSRKKRSRAAFSHAQVFELERRFAQQRYLSG 202
             ..||...||.|   |..||| .:|      |....:|::.|..||.||.:||||||.||||||.
Human    96 -PQDSSSKSPEP---SADESP-DNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSA 155

  Fly   203 PERSEMAKSLRLTETQVKIWFQNRRYKTKRKQIQQ-HEAALLGASKRVPVQVLVREDGSTTYA-- 264
            |||..:|..:|||.|||||||||.|||.||.:.:: .|...|.:.:||.|.|||| ||...:|
Human   156 PEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVR-DGKPCHALK 219

  Fly   265 --HMAAPGAGHGLDPALINIYRHQLQLAYGGLPLPQMQMPFPY---FYPQHKVPQPI 316
              .:||.....|:..:           ||....|..||....|   ..||:....|:
Human   220 AQDLAAATFQAGIPFS-----------AYSAQSLQHMQYNAQYSSASTPQYPTAHPL 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bap	NP_732637.1	Homeodomain	176..232	CDD:459649	36/55 (65%)
NKX2-2	NP_002500.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		20/60 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..131		14/51 (27%)
		Homeodomain	129..185	CDD:459649	36/55 (65%)