DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bap and Arx

DIOPT Version :9

Sequence 1:	NP_732637.1	Gene:	bap / 42537	FlyBaseID:	FBgn0004862	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001093644.1	Gene:	Arx / 317268	RGDID:	1562672	Length:	566	Species:	Rattus norvegicus

Alignment Length:	350	Identity:	86/350 - (24%)
Similarity:	122/350 - (34%)	Gaps:	123/350 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ETRRMSSVDSEPEPEKLKPSSDRE------RSISKSPPLCCRDLGLYKLTQPKEIQPSARQPSNY 94
            |...:...:.|.|.|:|....:.|      |::.|.|..|
  Rat   226 EEELLEDEEDEDEEEELLEDDEEELLEDDARALLKEPRRC------------------------- 265

  Fly    95 LQYYAAAMDNNNHHHQATGT-SNSSAADYMQRKLAYFGSTLAA-------PLDMRRCTSNDSDCD 151
                :.|         .||| :.::||......:|..|..|:.       |.|.......||.|.
  Rat   266 ----SVA---------TTGTVAAAAAAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCL 317

  Fly   152 SPPPLSSSPSESPLSHDGSGLSRK-KRSRAAFSHAQVFELERRFAQQRYLSGPERSEMAKSLRLT 215
            |    :.|.||..|      |.|| :|.|..|:..|:.||||.|.:..|.....|.|:|..|.||
  Rat   318 S----AGSDSEEGL------LKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLT 372

  Fly   216 ETQVKIWFQNRRYKTKRKQIQQHEAALLGASKRVPVQVLVREDGSTTYAHMAAPG---AGHGLDP 277
            |.:|::||||||.|.::::       ..||....|              .:..||   |.|.|.|
  Rat   373 EARVQVWFQNRRAKWRKRE-------KAGAQTHPP--------------GLPFPGPLSATHPLSP 416

  Fly   278 ALINIYRHQLQLAYGGLPLPQMQMPFPYFYPQHKVPQPIPPPTQSSSFVTASSASSSPVPI--PI 340
            .|                   ...|||   |.|        |...|::..|::|:::..|.  |.
  Rat   417 YL-------------------DASPFP---PHH--------PALDSAWTAAAAAAAAAFPSLPPP 451

  Fly   341 PGAVRPQRTPCPSPNGQMMSVESGA 365
            ||:.  ...|..:|.|  :|...||
  Rat   452 PGSA--SLPPSGAPLG--LSTFLGA 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bap	NP_732637.1	Homeobox	178..231	CDD:278475	24/52 (46%)
Arx	NP_001093644.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	50..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..264		9/37 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..319		9/36 (25%)
		Homeobox	336..388	CDD:278475	24/51 (47%)
		OAR	530..547	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	534..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910