DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bap and NOBOX

DIOPT Version :9

Sequence 1:	NP_732637.1	Gene:	bap / 42537	FlyBaseID:	FBgn0004862	Length:	382	Species:	Drosophila melanogaster
Sequence 2:	NP_001073882.3	Gene:	NOBOX / 135935	HGNCID:	22448	Length:	691	Species:	Homo sapiens

Alignment Length:	397	Identity:	85/397 - (21%)
Similarity:	129/397 - (32%)	Gaps:	151/397 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PEPEKLKPSSDRERSISKSPPL-----CCRDLGLYKLTQPKEIQPSARQPSNYLQYYAAAMDNNN 106
            |.|....|..|  |::::|.|.     |...:|..|:
Human   160 PPPRSRAPHKD--RTLARSRPQTQGEDCSLPVGEVKI---------------------------- 194

  Fly   107 HHHQATGTSNSSAADYMQRKLAYFG----STLAAPLDMRRCTSNDSDCDS---PPPLSSSPSESP 164
                  |..:.|.|...|:|....|    |:..|| :..|.|.|...|.|   |..|::..|...
Human   195 ------GKRSYSPAPGKQKKPNAMGLAPTSSPGAP-NSARATHNPVPCGSGRGPCHLANLLSTLA 252

  Fly   165 LSHDGSGLSR---------KKRSRAAFSHAQVFELERRFAQQRYLSGPERSEMAKSLRLTETQVK 220
            .|:......:         :|::|..:...|:.|||:.|.:..|....:|.|:|:::.:|..::.
Human   253 QSNQNRDHKQGPPEVTCQIRKKTRTLYRSDQLEELEKIFQEDHYPDSDKRREIAQTVGVTPQRIM 317

  Fly   221 --------------------------------IWFQNRRYKTKRKQIQQHEAALLGASKRVPVQV 253
                                            :||||||.|.::.:
Human   318 VKGAGSLVAGWSGGGPTIETLELQSERSAVAWVWFQNRRAKWRKME------------------- 363

  Fly   254 LVREDGSTTYAHMAAPGAGHGLDPALINIYRHQLQLAYGGLPLPQMQM---PFPYFYPQHKVPQP 315
              :.:|..:..:.||||      ||     ..|...|...||...|:.   |||...|....|:|
Human   364 --KLNGKESKDNPAAPG------PA-----SSQCSSAAEILPAVPMEPKPDPFPQESPLDTFPEP 415

  Fly   316 IP---------PPTQSSS----FVTASSASSSPV-----PIPIPGAVRPQRTPCPSPNGQMMSVE 362
             |         .|||.|.    .||....|..||     |.|:.....||..|.      :|.|
Human   416 -PMLLTSDQTLAPTQPSEGAQRVVTPPLFSPPPVRRADLPFPLGPVHTPQLMPL------LMDV- 472

  Fly   363 SGAESVH 369
            :|::|.|
Human   473 AGSDSSH 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bap	NP_732637.1	Homeobox	178..231	CDD:278475	18/84 (21%)
NOBOX	NP_001073882.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..233		22/109 (20%)
		homeodomain	273..363	CDD:238039	19/89 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	366..385		8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..437		12/43 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	635..691
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910