Protein Alignment tin and NKX2-1

DIOPT Version :9

• Sequence 1: NP_524433.1
• Gene: tin / 42536
• FlyBaseID: FBgn0004110
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: NP_001073136.1
• Gene: NKX2-1 / 7080
• HGNCID: 11825
• Length: 401
• Species: Homo sapiens
• Alignment Length: 448
• Identity: 113/448 - (25%)
• Similarity: 158/448 - (35%)
• Gaps: 175/448 - (39%)

  Fly     8 QAQSGGYYDHYTQSPSPGSLTNADAL-----NTTPFSVKDILNMVNQTEAYEGSYGHIDGAATAS 67
            :|.:||       ..|||.|:....:     :||||||.|||:.:.::....|..|...||..|:
Human    13 EAAAGG-------RSSPGRLSRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAA 70

  Fly    68 ALFAAGEYQNPHQYLNHQQHQQSELPIPQQQLHHQHLDDGATTSSSLSPLLPPPPHQLYGGYQDY 132
                            ::|.|.:                              ||
Human    71 ----------------YRQGQAA------------------------------PP---------- 79

  Fly   133 GMPAHMFQHHHGHPHQSFQHSA--SAYNMSASQFYAGASATAYQTPATYNYNYAGSGEVYGGATP 195
              .|.|.||..||      |.|  :||:|:|    ||....::              ...||...
Human    80 --TAAMQQHAVGH------HGAVTAAYHMTA----AGVPQLSH--------------SAVGGYCN 118

  Fly   196 SAVGIKSEYIPTPYVTPSPTLDLNSSAEVDSLQAPTQKLCVNPLSQRLMETASNSSSLRSIYGSD 260
            ..:|..|| :| ||                                  .:|..||:|....||::
Human   119 GNLGNMSE-LP-PY----------------------------------QDTMRNSASGPGWYGAN 147

  Fly   261 EGAKKKDNSQVTSSRSELRKNSISGNSNPGSNSGSTKP---RMKRKPRVLFSQAQVLELECRFRL 322
            ...:....|:.....|.:..:.:.|..:.|..|.:..|   ..:||.|||||||||.|||.||:.
Human   148 PDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQ 212

  Fly   323 KKYLTGAEREIIAQKLNLSATQVKIWFQNRRYKSKR---------------------GDIDC--- 363
            :|||:..|||.:|..::|:.|||||||||.|||.||                     |...|
Human   213 QKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQ 277

  Fly   364 --------EGIAKHLKLKSEPLDSPTSLPPPIPNHVMWPPTMQ-QSQQQQQHHAQQQQ 412
                    ..:|..:.:|.   ..|.....|.|.    ..::| .:|||.||.||..|
Human   278 QQAQQQSPRRVAVPVLVKD---GKPCQAGAPAPG----AASLQGHAQQQAQHQAQAAQ 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tin	NP_524433.1	HOX	301..357	CDD:197696	36/55 (65%)
NKX2-1	NP_001073136.1	Homeobox	194..247	CDD:278475	34/52 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0842
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810