DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tin and nkx3-2

DIOPT Version :9

Sequence 1:	NP_524433.1	Gene:	tin / 42536	FlyBaseID:	FBgn0004110	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_835233.1	Gene:	nkx3-2 / 337865	ZFINID:	ZDB-GENE-030127-1	Length:	245	Species:	Danio rerio

Alignment Length:	198	Identity:	58/198 - (29%)
Similarity:	84/198 - (42%)	Gaps:	47/198 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 DSLQAPTQKLCVNPLSQRLMETASNSSSLRSIYGSDEG---------------AKKKDNSQVTSS 274
            |.:.||          :|..||...:      |.||.|               .|..|.:..|..
Zfish    43 DEMDAP----------ERSDETEHKN------YDSDSGLSEDNDAKAQIDAKPEKDADLADETDQ 91

  Fly   275 RSELR--KNSISGNSNPGSNSGSTKPRMKRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQK 337
            .|..:  .:.:|..:.....||....:.|::.|..||.|||.|||.||..::||:|.||..:|..
Zfish    92 ESAAKGLSDCVSDCNTAEEKSGDAPKQRKKRSRAAFSHAQVFELERRFNHQRYLSGPERADLAAS 156

  Fly   338 LNLSATQVKIWFQNRRYKSKRGDIDCEGIAKHLKLKSEPLDSPTSLPPPI--------PNHVMWP 394
            |.|:.|||||||||||||:||..:..:.:|      |.|.....::...:        |..::.|
Zfish   157 LKLTETQVKIWFQNRRYKTKRRQMAADLLA------SAPAAKKVAVKVLVRDDRRQYSPGELLRP 215

  Fly   395 PTM 397
            |.:
Zfish   216 PLL 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tin	NP_524433.1	HOX	301..357	CDD:197696	33/55 (60%)
nkx3-2	NP_835233.1	COG5576	65..>177	CDD:227863	40/111 (36%)
nkx3-2	NP_835233.1	Homeobox	123..176	CDD:278475	32/52 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0842
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810