DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tin and HOXD13

DIOPT Version :9

Sequence 1:	NP_524433.1	Gene:	tin / 42536	FlyBaseID:	FBgn0004110	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_000514.2	Gene:	HOXD13 / 3239	HGNCID:	5136	Length:	343	Species:	Homo sapiens

Alignment Length:	287	Identity:	71/287 - (24%)
Similarity:	109/287 - (37%)	Gaps:	72/287 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 GATTSSSLS------PLLPP---------------PPHQLYGGYQDYGMPAHMFQHHHGHPHQSF 150
            |:::|||.|      |..||               ||          ..||..:.:|.|:.:.|.
Human    84 GSSSSSSSSAVVAARPEAPPAKECPAPTPAAAAAAPP----------SAPALGYGYHFGNGYYSC 138

  Fly   151 QHSASAYNMSASQFYAGASATAYQTPATYNYNYAGSG----EVYGGATPSAVGIKSEYIPTPYVT 211
            :.|               .....|..|..:..:|..|    |.|...:    |:.|..:|...|
Human   139 RMS---------------HGVGLQQNALKSSPHASLGGFPVEKYMDVS----GLASSSVPANEV- 183

  Fly   212 PSPTLDLNSSAEVDSLQAPTQKLCVNPLSQRLMETASNSSSLRSIYGSDEGAKKKD-----NSQV 271
            |:      .:.||...|..|......|....::.|..:.......|.|.||.:...     ||||
Human   184 PA------RAKEVSFYQGYTSPYQHVPGYIDMVSTFGSGEPRHEAYISMEGYQSWTLANGWNSQV 242

  Fly   272 TSSRSELRKNSISGNSNPGSNSGSTKP-----RMKRKPRVLFSQAQVLELECRFRLKKYLTGAER 331
            ..::.:.:.:....:|.|| :....:|     |..||.||.:::.|:.|||..:.:.|::...:|
Human   243 YCTKDQPQGSHFWKSSFPG-DVALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKR 306

  Fly   332 EIIAQKLNLSATQVKIWFQNRRYKSKR 358
            ..|:...|||..||.|||||||.|.|:
Human   307 RRISAATNLSERQVTIWFQNRRVKDKK 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tin	NP_524433.1	HOX	301..357	CDD:197696	24/55 (44%)
HOXD13	NP_000514.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
		HoxA13_N	39..174	CDD:289085	23/118 (19%)
		polyalanine repeat	57..71
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..115		8/30 (27%)
		homeodomain	277..333	CDD:238039	24/55 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910