DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tin and nkx2.7

DIOPT Version :9

Sequence 1:	NP_524433.1	Gene:	tin / 42536	FlyBaseID:	FBgn0004110	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_571494.1	Gene:	nkx2.7 / 30694	ZFINID:	ZDB-GENE-990415-179	Length:	269	Species:	Danio rerio

Alignment Length:	217	Identity:	75/217 - (34%)
Similarity:	99/217 - (45%)	Gaps:	52/217 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 IPTPYV-TPSPTLD---------LN----SSAEVDSLQAPTQKLCVNPLSQRLMETASNSSSLRS 255
            :|:|.. ||....|         ||    ...|.||:  |.|.|.:..:...|      |.||..
Zfish     2 LPSPVTSTPFSVKDILKLEQQQALNPGVFMGVEQDSV--PLQSLQLQCMQNTL------SRSLDL 58

  Fly   256 IYGSDEG-----AKKKDNSQVTSSRSELRKNSISGN----------SNPGSNSGST-----KPRM 300
            :|..::|     .|..|...|.||.....:..:..|          |:..|.:|.|     |.|:
Zfish    59 LYSPEKGIPGEQVKCDDFDIVRSSCGSPTEEEMDANEETSMCPFTDSSYSSKNGETLREKPKQRL 123

  Fly   301 KRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQKLNLSATQVKIWFQNRRYKSKRGDIDCEG 365
            :|||||||||.||.|||.||:.::||:..||:.:|..|.|::|||||||||||||.||...|
Zfish   124 RRKPRVLFSQTQVFELERRFKQQRYLSAPERDHLALALKLTSTQVKIWFQNRRYKCKRQRQD--- 185

  Fly   366 IAKHLKLKSEPLDSPTSLPPPI 387
                   ||..|..|..:..|:
Zfish   186 -------KSLELAGPRRVAVPV 200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tin	NP_524433.1	HOX	301..357	CDD:197696	36/55 (65%)
nkx2.7	NP_571494.1	COG5576	87..210	CDD:227863	51/124 (41%)
nkx2.7	NP_571494.1	Homeobox	127..180	CDD:278475	34/52 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0842
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24340
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.870