DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tin and Nkx2-6

DIOPT Version :9

Sequence 1:	NP_524433.1	Gene:	tin / 42536	FlyBaseID:	FBgn0004110	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_035050.2	Gene:	Nkx2-6 / 18092	MGIID:	97351	Length:	289	Species:	Mus musculus

Alignment Length:	211	Identity:	72/211 - (34%)
Similarity:	94/211 - (44%)	Gaps:	50/211 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 TPSPTLDL--NSSAEVDSLQAPTQKLCVNPLSQRLMETASNSSSLRSIYGSDEGAKKKDNSQVTS 273
            ||....|:  ....:.||......:|..||:..|.:.....|....|          .|.:|...
Mouse     9 TPFSVADILRLECQQKDSKTLSQWELHRNPVKPRYLRMNQESGWFES----------SDRAQAVP 63

  Fly   274 SRS------ELRKNSIS------------GNSNP------GSNSG--------STKPRMKRKPRV 306
            .|.      |:..|.:.            |..||      |:.||        ||:.|.:||.||
Mouse    64 FRCTWETVLEMGSNPVGEPQTPPGTISRLGARNPMTDRGVGNLSGDMRRGGPVSTRTRPQRKSRV 128

  Fly   307 LFSQAQVLELECRFRLKKYLTGAEREIIAQKLNLSATQVKIWFQNRRYKSKRGDIDCEGIAKHLK 371
            ||||||||.||.||:.::|||..|||.:|..|.|::|||||||||||||||....|     :.|:
Mouse   129 LFSQAQVLALERRFKQQRYLTAPEREHLASALQLTSTQVKIWFQNRRYKSKSQRQD-----QTLE 188

  Fly   372 LKSEPLDSPTSLPPPI 387
            |...|| :|..:..|:
Mouse   189 LAGHPL-APRRVAVPV 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tin	NP_524433.1	HOX	301..357	CDD:197696	38/55 (69%)
Nkx2-6	NP_035050.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..125		10/49 (20%)
		Homeobox	126..179	CDD:278475	36/52 (69%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..289
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0842
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I4814
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24340
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.960