DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tin and Hoxd13

DIOPT Version :9

Sequence 1:	NP_524433.1	Gene:	tin / 42536	FlyBaseID:	FBgn0004110	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_032301.2	Gene:	Hoxd13 / 15433	MGIID:	96205	Length:	339	Species:	Mus musculus

Alignment Length:	321	Identity:	79/321 - (24%)
Similarity:	121/321 - (37%)	Gaps:	74/321 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 AATASALFAAGEYQNPHQYLNHQQHQQSELPIPQQQLHHQHLDDGATTSSSLSPLLP-------- 119
            ||.|:|..||..:..|         ..||             ..|:::|||.|.::.
Mouse    58 AAAAAAAAAASSFAYP---------GTSE-------------RTGSSSSSSSSAVIATRPEAPVA 100

  Fly   120 ---PPPHQLYGGYQDYGMPAHMFQHHHGHPHQSFQHSASAYNMSASQFYAGASATAYQTPATYNY 181
               |.|..........|.||..:.:|.|:.:.|.:.|               .....|..|..:.
Mouse   101 KECPAPAAAATAAAPPGAPALGYGYHFGNGYYSCRMS---------------HGVGLQQNALKSS 150

  Fly   182 NYAGSG----EVYGGATPSAVGIKSEYIPTPYVTPSPTLDLNSSAEVDSLQAPTQKLCVNPLSQR 242
            .:|..|    |.|...:    |:.|..:||..| |:      .:.||...|..|......|....
Mouse   151 PHASLGGFPVEKYMDVS----GLASSSVPTNEV-PA------RAKEVSFYQGYTSPYQHVPGYID 204

  Fly   243 LMETASNSSSLRSIYGSDEGAKKKD-----NSQVTSSRSELRKNSISGNSNPGSNSGSTKP---- 298
            ::.|..:.......|.|.||.:...     ||||..::.:.:.:....:|.|| :....:|
Mouse   205 MVSTFGSGEPRHEAYISMEGYQSWTLANGWNSQVYCAKDQPQGSHFWKSSFPG-DVALNQPDMCV 268

  Fly   299 -RMKRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQKLNLSATQVKIWFQNRRYKSKR 358
             |..||.||.:::.|:.|||..:.:.|::...:|..|:...|||..||.|||||||.|.|:
Mouse   269 YRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRRVKDKK 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tin	NP_524433.1	HOX	301..357	CDD:197696	24/55 (44%)
Hoxd13	NP_032301.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		HoxA13_N	<121..168	CDD:403486	10/65 (15%)
		Homeobox	275..329	CDD:395001	22/53 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910