DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIFaR and CCKAR

DIOPT Version :9

Sequence 1:	NP_001163674.1	Gene:	SIFaR / 42530	FlyBaseID:	FBgn0038880	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_000721.1	Gene:	CCKAR / 886	HGNCID:	1570	Length:	428	Species:	Homo sapiens

Alignment Length:	362	Identity:	104/362 - (28%)
Similarity:	177/362 - (48%)	Gaps:	72/362 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 VYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPW 274
            |..:.|.::||:.::||:.||.|::|..|||||||.|:::||::|:::.:||:|..||.|:...:
Human    43 VQILLYSLIFLLSVLGNTLVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDF 107

  Fly   275 MLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQ---MTKRRARIMIIGIWVIALVT 336
            :.|..:||...|..|.||:.|.::|:|:||:|:.||..||:.   .||..|..:|...|.::...
Human   108 IFGSAVCKTTTYFMGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTI 172

  Fly   337 TIPWLLFFDLVP-AEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITL 400
            ..|:.::.:||| .:.....|.:..:..|..:.|:.|..       |||..|   :|:|..::.:
Human   173 MTPYPIYSNLVPFTKNNNQTANMCRFLLPNDVMQQSWHT-------FLLLIL---FLIPGIVMMV 227

  Fly   401 CYVLIWI-------------------KVSTRSIPGESKDA-----QMDRMQQK------------ 429
            .|.||.:                   |.||.| .|:.:|:     |..|..:|
Human   228 AYGLISLELYQGIKFEASQKKSAKERKPSTTS-SGKYEDSDGCYLQKTRPPRKLELRQLSTGSSS 291

  Fly   430 ---------------SKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMPV 479
                           :|.:||:||:.:|:||.|.|:|::...|...:  |.:..|..:....:..
Human   292 RANRIRSNSSAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAY--DTASAERRLSGTPISF 354

  Fly   480 AQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCC 515
            ...|..::||:|||:|. :||::|.||.|..   .||
Human   355 ILLLSYTSSCVNPIIYCFMNKRFRLGFMATF---PCC 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	78/281 (28%)
SIFaR	NP_001163674.1	7tm_1	225..495	CDD:278431	91/324 (28%)
CCKAR	NP_000721.1	CholecysA-Rec_N	1..47	CDD:286302	1/3 (33%)
		7tm_4	48..>196	CDD:304433	53/147 (36%)
		7tm_1	58..370	CDD:278431	91/324 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	248..272		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910