Protein Alignment SIFaR and GALR3

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_003605.1
• Gene: GALR3 / 8484
• HGNCID: 4134
• Length: 368
• Species: Homo sapiens
• Alignment Length: 367
• Identity: 93/367 - (25%)
• Similarity: 166/367 - (45%)
• Gaps: 76/367 - (20%)

  Fly   213 VAYIVVFLVGLIGNSFVIAVVLRA-----PRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFV 272
            |.:.::||:|.:||..|:||:|:.     ....:.|:.||:|||:||:..|:.|:|.........
Human    22 VVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLD 86

  Fly   273 PWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQ---MTKRRARIMIIGIWVIAL 334
            .|:.|.|:||.|..:..:::.||.::|.|||:||::|:..||:.   .|.|.||..:..:|::|.
Human    87 AWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAA 151

  Fly   335 VTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFL-LANLVACYLLPMSLI 398
            :.:.|:|.::..|            .|...: ||...|   .|.....| :|...|.||||::::
Human   152 LFSAPYLSYYGTV------------RYGALE-LCVPAW---EDARRRALDVATFAAGYLLPVAVV 200

  Fly   399 TLCY----VLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVI---- 455
            :|.|    ..:|..|.    |..:..|:..|   ::..:..:.::||..|:.|.|.|.:.:
Human   201 SLAYGRTLRFLWAAVG----PAGAAAAEARR---RATGRAGRAMLAVAALYALCWGPHHALILCF 258

  Fly   456 -FARIKFGSDISQEEFEILKKVMP-------VAQWLGSSNSCINPILYSVNKKYRRGFAAIIKSR 512
             :.|..|.               |       .:..|..:|||:||::|::..::   |.|..:..
Human   259 WYGRFAFS---------------PATYACRLASHCLAYANSCLNPLVYALASRH---FRARFRRL 305

  Fly   513 SCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNA 554
            ..|||.|.:          ..|::....:.:|...|...|:|
Human   306 WPCGRRRRH----------RARRALRRVRPASSGPPGCPGDA 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	82/316 (26%)
		TM helix 1	210..236	CDD:320124	10/22 (45%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	12/29 (41%)
		TM helix 4	322..340	CDD:320124	4/17 (24%)
		TM helix 5	379..404	CDD:320124	9/29 (31%)
		TM helix 6	429..459	CDD:320124	6/34 (18%)
		TM helix 7	474..498	CDD:320124	8/30 (27%)
GALR3	NP_003605.1	7tmA_Gal2_Gal3_R	18..302	CDD:320225	84/320 (26%)
		TM helix 1	19..45	CDD:320225	10/22 (45%)
		TM helix 2	57..83	CDD:320225	11/25 (44%)
		TM helix 3	95..125	CDD:320225	12/29 (41%)
		TM helix 4	137..157	CDD:320225	5/19 (26%)
		TM helix 5	181..210	CDD:320225	9/28 (32%)
		TM helix 6	228..258	CDD:320225	6/29 (21%)
		TM helix 7	270..295	CDD:320225	7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..368		5/21 (24%)