Protein Alignment SIFaR and KISS1R

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: XP_047295501.1
• Gene: KISS1R / 84634
• HGNCID: 4510
• Length: 459
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 109/438 - (24%)
• Similarity: 170/438 - (38%)
• Gaps: 146/438 - (33%)

  Fly   163 SPATTSLISAAAATKSYNDSALRWEQLDG------SVDFGFDPLYRHSLAMSMVYCVAYIVVFLV 221
            :||..|......|..|           ||      :||....||:             :..:.|:
Human    15 APANASGCPGCGANAS-----------DGPVPSPRAVDAWLVPLF-------------FAALMLL 55

  Fly   222 GLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPY 286
            ||:|||.||.|:.|...||||||::|.|||..|:..::.|:|.|.:......|:||..|||||.|
Human    56 GLVGNSLVIYVICRHKPMRTVTNFYIANLAATDVTFLLCCVPFTALLYPLPGWVLGDFMCKFVNY 120

  Fly   287 IQGVSVAASVYSLIAVSLDRFIAIWWPLKQMTKRRARIMI---IGIWVIALVTTIPWLLFFDLVP 348
            ||.|||.|:..:|.|:|:||:....:||:.:.:|..|:.:   :.|||.:...:.|.|....|.|
Human   121 IQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSP 185

  Fly   349 AEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWI---KVS 410
            .              |:..|.|.:|....... |.|.||:|.||||:.....||..:..   :|:
Human   186 G--------------PRAYCSEAFPSRALERA-FALYNLLALYLLPLLATCACYAAMLRHLGRVA 235

  Fly   411 TRSIPGES---------KDAQM-------------------------------DRMQQKS----- 430
            .|..|.:|         :.|::                               |.:.:..
Human   236 VRPAPADSALQVRGVGGRTARLGGRGGTVVGGAGGGICAGRDSPRGPGGAVRGDELSRAPAFRLT 300

  Fly   431 ------------------KVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVM 477
                              :.||.:::.|||:||...|.|:.:               |.:|:.:.
Human   301 TFTAPPQGQVLAERAGAVRAKVSRLVAAVVLLFAACWGPIQL---------------FLVLQALG 350

  Fly   478 PVAQW----------------LGSSNSCINPILYS-VNKKYRRGFAAI 508
            |...|                :..|||.:||:||: :...:|:.|..:
Human   351 PAGSWHPRSYAAYALKTWAHCMSYSNSALNPLLYAFLGSHFRQAFRRV 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	97/381 (25%)
		TM helix 1	210..236	CDD:320124	9/25 (36%)
		TM helix 2	243..269	CDD:320124	10/25 (40%)
		TM helix 3	281..311	CDD:320124	16/29 (55%)
		TM helix 4	322..340	CDD:320124	4/20 (20%)
		TM helix 5	379..404	CDD:320124	11/24 (46%)
		TM helix 6	429..459	CDD:320124	9/52 (17%)
		TM helix 7	474..498	CDD:320124	9/40 (23%)
KISS1R	XP_047295501.1	7tm_GPCRs	43..395	CDD:475119	99/394 (25%)
		TM helix 1	45..69	CDD:410628	11/36 (31%)
		TM helix 2	78..100	CDD:410628	8/21 (38%)
		TM helix 3	116..138	CDD:410628	12/21 (57%)
		TM helix 4	161..177	CDD:410628	3/15 (20%)
		TM helix 5	202..225	CDD:410628	10/23 (43%)
		TM helix 6	323..345	CDD:410628	8/36 (22%)
		TM helix 7	363..388	CDD:410628	7/24 (29%)