Protein Alignment SIFaR and Kiss1r

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_076482.2
• Gene: Kiss1r / 78976
• RGDID: 70930
• Length: 396
• Species: Rattus norvegicus
• Alignment Length: 362
• Identity: 105/362 - (29%)
• Similarity: 165/362 - (45%)
• Gaps: 75/362 - (20%)

  Fly   215 YIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWL 279
            :..:.|:||:|||.||.|:.|...|:||||::|.|||..|:..::.|:|.|.:......|:||..
  Rat    49 FAALMLLGLVGNSLVIFVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPTWVLGDF 113

  Fly   280 MCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQMTKRRARIMI---IGIWVIALVTTIPWL 341
            |||||.|||.|||.|:..:|.|:|:||:....:||:.:.:|..|:.:   :.|||.:...:.|.|
  Rat   114 MCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALTVSLSIWVGSAAVSAPVL 178

  Fly   342 LFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIW 406
            ....|.|.              |...|.|.:|....... |.|.||:|.||||:.....||..:.
  Rat   179 ALHRLSPG--------------PHTYCSEAFPSRALERA-FALYNLLALYLLPLLATCACYGAML 228

  Fly   407 IKVSTRSI-PGESKDA-QMDRMQQKS---KVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDIS 466
            ..:...:: |..:..| |...:.|::   :.||.:::.|||:||...|.|:.:
  Rat   229 RHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQL------------ 281

  Fly   467 QEEFEILKKVMPVAQW----------------LGSSNSCINPILYS-VNKKYRRGFAAIIKSRSC 514
               |.:|:.:.|...|                :..|||.:||:||: :...:|:.|.     |.|
  Rat   282 ---FLVLQALGPSGAWHPRSYAAYALKIWAHCMSYSNSALNPLLYAFLGSHFRQAFC-----RVC 338

  Fly   515 -CGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSS 550
             ||..|              ::..|...:|.|.:|.|
  Rat   339 PCGPQR--------------QRRPHASAHSDRAAPHS 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	94/314 (30%)
		TM helix 1	210..236	CDD:320124	9/20 (45%)
		TM helix 2	243..269	CDD:320124	10/25 (40%)
		TM helix 3	281..311	CDD:320124	16/29 (55%)
		TM helix 4	322..340	CDD:320124	4/20 (20%)
		TM helix 5	379..404	CDD:320124	11/24 (46%)
		TM helix 6	429..459	CDD:320124	9/32 (28%)
		TM helix 7	474..498	CDD:320124	9/40 (23%)
Kiss1r	NP_076482.2	7tmA_KiSS1R	43..334	CDD:320223	94/314 (30%)
		TM helix 1	44..70	CDD:320223	9/20 (45%)
		TM helix 2	77..103	CDD:320223	10/25 (40%)
		TM helix 3	115..145	CDD:320223	16/29 (55%)
		TM helix 4	157..177	CDD:320223	4/19 (21%)
		TM helix 5	201..230	CDD:320223	11/29 (38%)
		TM helix 6	256..286	CDD:320223	10/44 (23%)
		TM helix 7	302..327	CDD:320223	7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	346..396		5/16 (31%)