Protein Alignment SIFaR and TACR1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001049.1
• Gene: TACR1 / 6869
• HGNCID: 11526
• Length: 407
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 104/369 - (28%)
• Similarity: 175/369 - (47%)
• Gaps: 49/369 - (13%)

  Fly   209 MVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVP 273
            :::..||.|:.:..::||..|:.::|...|||||||||:||||.|:..:..|.........:...
Human    33 VLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNE 97

  Fly   274 WMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKRRARIMIIGIWVIALVTT 337
            |..|...|||..:....:|.||:||:.||:.||::||..||: :::....:::|..|||:||:..
Human    98 WYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLA 162

  Fly   338 IP--WLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWP--PGTDGNLYFLLANLVACYLLPMSLI 398
            .|  :....:.:|:..|               |...||  |.......:.:...|..|.||:.:|
Human   163 FPQGYYSTTETMPSRVV---------------CMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVI 212

  Fly   399 TLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGS 463
            ...|.::.|.:....|||:|.|...:  |..:|.||:||::.||..|.:.|||.::.|.......
Human   213 GYAYTVVGITLWASEIPGDSSDRYHE--QVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINP 275

  Fly   464 DISQEEFEILKKVMPVAQWLGSSNSCINPILY-SVNKKYRRGFAAIIKSRSCCGRL--------- 518
            |:..::|  :::|.....||..|::..|||:| .:|.::|.||....:   ||..:
Human   276 DLYLKKF--IQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFR---CCPFISAGDYEGLE 335

  Fly   519 ----RYYD------NVAIASSTTSTRKSSHYH--QNSSRKSPSS 550
                ||..      .|:...:|.||...:|..  ::..:.:|||
Human   336 MKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSS 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	90/301 (30%)
		TM helix 1	210..236	CDD:320124	7/25 (28%)
		TM helix 2	243..269	CDD:320124	10/25 (40%)
		TM helix 3	281..311	CDD:320124	13/29 (45%)
		TM helix 4	322..340	CDD:320124	7/19 (37%)
		TM helix 5	379..404	CDD:320124	6/24 (25%)
		TM helix 6	429..459	CDD:320124	12/29 (41%)
		TM helix 7	474..498	CDD:320124	8/24 (33%)
TACR1	NP_001049.1	7tmA_NK1R	33..316	CDD:320668	90/301 (30%)
		TM helix 1	34..60	CDD:320668	7/25 (28%)
		TM helix 2	67..93	CDD:320668	10/25 (40%)
		TM helix 3	105..135	CDD:320668	13/29 (45%)
		TM helix 4	146..167	CDD:320668	7/20 (35%)
		TM helix 5	193..222	CDD:320668	6/28 (21%)
		TM helix 6	241..271	CDD:320668	12/29 (41%)
		TM helix 7	284..309	CDD:320668	8/24 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..407		4/16 (25%)