Protein Alignment SIFaR and SSTR5

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001044.1
• Gene: SSTR5 / 6755
• HGNCID: 11334
• Length: 364
• Species: Homo sapiens
• Alignment Length: 364
• Identity: 105/364 - (28%)
• Similarity: 178/364 - (48%)
• Gaps: 65/364 - (17%)

  Fly   174 AATKSYNDSALRWEQLDGSVDFGFDPLYRHSL--------AMSMVYCVAYIVVFLVGLIGNSFVI 230
            |:|.|:|.|:      .|:...|.|   ..:|        |.:::..|.|::|...||.||:.||
Human     7 ASTPSWNASS------PGAASGGGD---NRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVI 62

  Fly   231 AVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAAS 295
            .||||..:|:||||.:|:|||:||:|.:: .||.....|....|..|.::|:.|..:.||:...|
Human    63 YVVLRFAKMKTVTNIYILNLAVADVLYML-GLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTS 126

  Fly   296 VYSLIAVSLDRFIAIWWPLKQMTKRRARIMII---GIWVIALVTTIPWLLFFDLVPAEEVFSDAL 357
            |:.|..:|:||::|:..||.....||.|:..:   ..||::|..::|.|:|.|:
Human   127 VFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADV----------- 180

  Fly   358 VSAYSQPQFLCQEVWPP--GTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKD 420
                 |....|...||.  |..|.: |::...|..:..|:.:|.|||:||.:||....:
Human   181 -----QEGGTCNASWPEPVGLWGAV-FIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGV------ 233

  Fly   421 AQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEE-------FEILKKVMP 478
             ::..::::|:.||.:|::.||::|...|||.:.:.. :.....:.||.       |.::
Human   234 -RVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNI-VNLAVALPQEPASAGLYFFVVI----- 291

  Fly   479 VAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCCG 516
                |..:|||.||:||. ::..:|:.|..::..|...|
Human   292 ----LSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSG 326

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	92/308 (30%)
		TM helix 1	210..236	CDD:320124	12/25 (48%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	11/29 (38%)
		TM helix 4	322..340	CDD:320124	4/20 (20%)
		TM helix 5	379..404	CDD:320124	7/24 (29%)
		TM helix 6	429..459	CDD:320124	10/29 (34%)
		TM helix 7	474..498	CDD:320124	8/24 (33%)
SSTR5	NP_001044.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		6/18 (33%)
		7tmA_SSTR5	51..315	CDD:320640	89/298 (30%)
		TM helix 2	75..101	CDD:320640	11/26 (42%)
		TM helix 3	112..142	CDD:320640	11/29 (38%)
		TM helix 4	154..176	CDD:320640	5/21 (24%)
		TM helix 5	198..227	CDD:320640	10/29 (34%)
		TM helix 6	241..271	CDD:320640	10/30 (33%)
		TM helix 7	283..308	CDD:320640	9/33 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..364		105/364 (29%)