Protein Alignment SIFaR and SSTR4

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001043.2
• Gene: SSTR4 / 6754
• HGNCID: 11333
• Length: 388
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 98/313 - (31%)
• Similarity: 169/313 - (53%)
• Gaps: 33/313 - (10%)

  Fly   207 MSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIF 271
            |..:.|: |.:|.||||:||:.||.|:||..:|:|.||.:::|||:||.| .:..:|........
Human    47 MVAIQCI-YALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADEL-FMLSVPFVASSAAL 109

  Fly   272 VPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQMTKRR---ARIMIIGIWVIA 333
            ..|..|.::|:.|..:.|:::..||:.|..:|:||::|:..||:..|.||   |:::.:|:|:.:
Human   110 RHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLAS 174

  Fly   334 LVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWP-PGTDGNLYFLLANLVACYLLPMSL 397
            |:.|:|..:|.|..||.           ......|...|| |.  .:..|::...:..:|||:..
Human   175 LLVTLPIAIFADTRPAR-----------GGQAVACNLQWPHPA--WSAVFVVYTFLLGFLLPVLA 226

  Fly   398 ITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFG 462
            |.|||:||..|:  |::...:...|    :::|:.|:.::::.||::|||.|:|.||:.....|.
Human   227 IGLCYLLIVGKM--RAVALRAGWQQ----RRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFV 285

  Fly   463 SDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSC 514
            :.:.       ..|..|:..|..:|||.|||||. ::..:||.|..::..|.|
Human   286 TSLD-------ATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCC 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	94/300 (31%)
		TM helix 1	210..236	CDD:320124	13/25 (52%)
		TM helix 2	243..269	CDD:320124	9/25 (36%)
		TM helix 3	281..311	CDD:320124	10/29 (34%)
		TM helix 4	322..340	CDD:320124	5/17 (29%)
		TM helix 5	379..404	CDD:320124	8/24 (33%)
		TM helix 6	429..459	CDD:320124	11/29 (38%)
		TM helix 7	474..498	CDD:320124	11/24 (46%)
SSTR4	NP_001043.2	7tmA_SSTR4	48..322	CDD:320639	94/301 (31%)
		TM helix 1	49..75	CDD:320639	13/26 (50%)
		TM helix 2	82..108	CDD:320639	9/26 (35%)
		TM helix 3	119..149	CDD:320639	10/29 (34%)
		TM helix 4	161..183	CDD:320639	6/21 (29%)
		TM helix 5	208..237	CDD:320639	10/28 (36%)
		TM helix 6	252..282	CDD:320639	11/29 (38%)
		TM helix 7	290..315	CDD:320639	11/24 (46%)