Protein Alignment SIFaR and SSTR3

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001042.1
• Gene: SSTR3 / 6753
• HGNCID: 11332
• Length: 418
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 128/464 - (27%)
• Similarity: 204/464 - (43%)
• Gaps: 81/464 - (17%)

  Fly   171 SAAAATKSYNDSALRW--EQLDGSVDFGFDPLYRHSLAMSMVYC-VAYIVVFLVGLIGNSFVIAV 232
            |:.:.|....:::..|  :...|:|..|..|.   .||:|.|.. :.|:||.:|||:|||.||.|
Human     7 SSVSTTSEPENASSAWPPDATLGNVSAGPSPA---GLAVSGVLIPLVYLVVCVVGLLGNSLVIYV 68

  Fly   233 VLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVY 297
            |||.....:|||.:|:|||:||.| .:..||.....|....|..|.|||:.|..:.|::...|::
Human    69 VLRHTASPSVTNVYILNLALADEL-FMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIF 132

  Fly   298 SLIAVSLDRFIAIWWPLKQMTKRR---ARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVS 359
            .|..:|:||::|:..|.:....|.   ||.:...:||.:.|..:|.::|               |
Human   133 CLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVF---------------S 182

  Fly   360 AYSQPQFLCQEVWP-PGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQM 423
            ...:....|...|| |.......|::......:..|:.:|.|||:||.:||.:   .|....|..
Human   183 GVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRS---AGRRVWAPS 244

  Fly   424 DRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKKVMPVAQ------- 481
            .:.:::|:.:|.:|:||||.||||.|:|.||:               .|:..|.|:.:
Human   245 CQRRRRSERRVTRMVVAVVALFVLCWMPFYVL---------------NIVNVVCPLPEEPAFFGL 294

  Fly   482 -----WLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYH 540
                 .|..:|||.|||||. ::.::::||..::...|  .|:|..:........|.........
Human   295 YFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPS--RRVRSQEPTVGPPEKTEEEDEEEED 357

  Fly   541 QNSSRKSPSSKGNAVSYIYEHNSLRRHNMMLKQDSNLSQQMLLKQDSHGSR-----QFLIKQESS 600
            ...||:....|        |.|.         :.|.::|.....|:...||     |.|:.||:|
Human   358 GEESREGGKGK--------EMNG---------RVSQITQPGTSGQERPPSRVASKEQQLLPQEAS 405

  Fly   601 CSDASGIRR 609
            ..:.|...|
Human   406 TGEKSSTMR 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	95/313 (30%)
		TM helix 1	210..236	CDD:320124	15/26 (58%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	9/29 (31%)
		TM helix 4	322..340	CDD:320124	5/17 (29%)
		TM helix 5	379..404	CDD:320124	6/24 (25%)
		TM helix 6	429..459	CDD:320124	15/29 (52%)
		TM helix 7	474..498	CDD:320124	11/36 (31%)
SSTR3	NP_001042.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		2/13 (15%)
		7tm_GPCRs	45..324	CDD:475119	95/312 (30%)
		TM helix 1	47..71	CDD:410628	13/23 (57%)
		TM helix 2	80..101	CDD:410628	10/21 (48%)
		TM helix 3	117..139	CDD:410628	4/21 (19%)
		TM helix 4	162..178	CDD:410628	3/15 (20%)
		TM helix 5	204..227	CDD:410628	5/22 (23%)
		TM helix 6	256..278	CDD:410628	13/36 (36%)
		TM helix 7	292..317	CDD:410628	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..418		19/97 (20%)