Protein Alignment SIFaR and oprm1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_571782.2
• Gene: oprm1 / 65088
• ZFINID: ZDB-GENE-010125-1
• Length: 382
• Species: Danio rerio
• Alignment Length: 441
• Identity: 103/441 - (23%)
• Similarity: 206/441 - (46%)
• Gaps: 94/441 - (21%)

  Fly   138 GSLAGKSLAIAD---ATSSTYYSNLLNLSPATTSLISAAAATKSYNDSAL-RWEQLDGSVDFGFD 198
            |:::....|:::   :.||.:..|..|    ::.|:       :.|.|.. |..:||.|
Zfish     6 GNISDLLYALSNPMVSNSSIFCRNFSN----SSGLV-------NMNSSVCDRTPELDKS------ 53

  Fly   199 PLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLP 263
               ...:.::::....|.:|.::||:||..|:.|::|..:|:|.||.:|.|||:||.|. ...||
Zfish    54 ---STPVIVAIIITALYSIVCVMGLVGNVLVMYVIIRYTKMKTATNIYIFNLALADSLA-TSTLP 114

  Fly   264 ATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQM---TKRRARIM 325
            ...:..:...|..|..:||.|..|...::..|:::|..:|:||:||:..|:|.:   |.|.|:|:
Zfish   115 FQSVNYLMGTWPFGDELCKIVMSIDYYNMFTSIFTLTTMSVDRYIAVCHPVKALDFRTPRNAKIV 179

  Fly   326 IIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWP-PGTDGNLYFLLANLVA 389
            .:..|:::....:|.::...  ...::.|:.::.        |..::| |.........:...:.
Zfish   180 NVCNWILSSAIGLPVMVMAS--TTSDLHSNGIID--------CTLLFPHPSWYWENLLKICVFIF 234

  Fly   390 CYLLPMSLITLCYVLIWIKV-STRSIPG-ESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPL 452
            .:::|:.:||:||.|:.::: |.|.:.| :.||..:.|        :.:|::.||.:|::.|.|:
Zfish   235 AFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRR--------ITRMVLVVVAVFIVCWTPI 291

  Fly   453 YVIFARIKFGSDISQEEFEILKKVMPVAQ-------W-----LGSSNSCINPILYS-VNKKYRRG 504
            ::               |.|:|.::.:..       |     ||.:|||:||:||: :::.::|.
Zfish   292 HI---------------FVIIKALVTIPNSLLQTITWHFCIALGYTNSCLNPVLYAFLDENFKRC 341

  Fly   505 FAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAV 555
            |      |..|          :.|.:....::|...:|..|...|| |:.|
Zfish   342 F------REFC----------VPSPSVLDLQNSTRSRNPQRDGQSS-GHTV 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	79/314 (25%)
		TM helix 1	210..236	CDD:320124	8/25 (32%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	11/29 (38%)
		TM helix 4	322..340	CDD:320124	3/17 (18%)
		TM helix 5	379..404	CDD:320124	5/24 (21%)
		TM helix 6	429..459	CDD:320124	6/29 (21%)
		TM helix 7	474..498	CDD:320124	11/36 (31%)
oprm1	NP_571782.2	7tmA_Mu_opioid_R	61..342	CDD:320218	79/314 (25%)
		TM helix 1	62..88	CDD:320218	8/25 (32%)
		TM helix 2	95..121	CDD:320218	11/26 (42%)
		TM helix 3	132..162	CDD:320218	11/29 (38%)
		TM helix 4	174..196	CDD:320218	5/21 (24%)
		TM helix 5	224..253	CDD:320218	6/28 (21%)
		TM helix 6	268..298	CDD:320218	9/52 (17%)
		TM helix 7	310..335	CDD:320218	10/24 (42%)