DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIFaR and NPFFR1

DIOPT Version :9

Sequence 1:	NP_001163674.1	Gene:	SIFaR / 42530	FlyBaseID:	FBgn0038880	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_071429.1	Gene:	NPFFR1 / 64106	HGNCID:	17425	Length:	430	Species:	Homo sapiens

Alignment Length:	323	Identity:	111/323 - (34%)
Similarity:	179/323 - (55%)	Gaps:	10/323 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   197 FDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFC 261
            |...|:|:..::.::.|||.::||:.::||:.|..:||:...|.||||.||:|||::|:||.:||
Human    32 FSSYYQHTSPVAAMFIVAYALIFLLCMVGNTLVCFIVLKNRHMHTVTNMFILNLAVSDLLVGIFC 96

  Fly   262 LPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQ-MTKRRARIM 325
            :|.||:.|:...|......||....:||:||:|||::|:|::::||..|..|.:: :|.|:|.:.
Human    97 MPTTLVDNLITGWPFDNATCKMSGLVQGMSVSASVFTLVAIAVERFRCIVHPFREKLTLRKALVT 161

  Fly   326 IIGIWVIALVTTIPWLLFFDLVPAEEVFS-DALVSAYSQPQFLCQEVWPPGTDGNLY--FLLANL 387
            |..||.:||:...|..:...:...|..|. ||...:|  |.:.|.|.||......:|  .|.:::
Human   162 IAVIWALALLIMCPSAVTLTVTREEHHFMVDARNRSY--PLYSCWEAWPEKGMRRVYTTVLFSHI 224

  Fly   388 VACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFVLSWLPL 452
               ||.|::||.:.|..|..|:.....|....:...|....:.:.:|:.|||.|.:.|.||||||
Human   225 ---YLAPLALIVVMYARIARKLCQAPGPAPGGEEAADPRASRRRARVVHMLVMVALFFTLSWLPL 286

  Fly   453 YVIFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPILYS-VNKKYRRGFAAIIKSRSC 514
            :.:...|.:|...:.:...:.....|.|.||...||..|||:|. .|:.:||||.|..::|.|
Human   287 WALLLLIDYGQLSAPQLHLVTVYAFPFAHWLAFFNSSANPIIYGYFNENFRRGFQAAFRARLC 349

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	78/230 (34%)
SIFaR	NP_001163674.1	7tm_1	225..495	CDD:278431	94/273 (34%)
NPFFR1	NP_071429.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		7tm_GPCRs	44..340	CDD:333717	103/300 (34%)
		TM helix 1	46..70	CDD:320095	9/23 (39%)
		TM helix 2	79..101	CDD:320095	12/21 (57%)
		TM helix 3	117..139	CDD:320095	10/21 (48%)
		TM helix 4	160..176	CDD:320095	5/15 (33%)
		TM helix 5	214..237	CDD:320095	7/25 (28%)
		TM helix 6	266..291	CDD:320095	12/24 (50%)
		TM helix 7	308..333	CDD:320095	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160514
Domainoid	1	1.000	183	1.000	Domainoid score	I3427
eggNOG	1	0.900	-	-		E33208_3BBX5
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3671
Isobase	1	0.950	-	0	Normalized mean entropy	S6558
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42029
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.840