DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIFaR and RHO

DIOPT Version :10

Sequence 1:NP_650966.2 Gene:SIFaR / 42530 FlyBaseID:FBgn0038880 Length:758 Species:Drosophila melanogaster
Sequence 2:NP_000530.1 Gene:RHO / 6010 HGNCID:10012 Length:348 Species:Homo sapiens


Alignment Length:338 Identity:77/338 - (22%)
Similarity:155/338 - (45%) Gaps:50/338 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   214 AYIVVFLV-GLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLG 277
            ||:.:.:| |...|...:.|.::..::||..||.::|||:||:.:::....:||..::...::.|
Human    42 AYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFG 106

  Fly   278 WLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK--QMTKRRARIMIIGIWVIALVTTIPW 340
            ...|....:...:....:::||:.::::|::.:..|:.  :..:..|.:.:...||:||....|.
Human   107 PTGCNLEGFFATLGGEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPP 171

  Fly   341 LLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLI 405
            |..:.....|.:.....:..|:    |..||      .|..|::...|..:.:||.:|..||..:
Human   172 LAGWSRYIPEGLQCSCGIDYYT----LKPEV------NNESFVIYMFVVHFTIPMIIIFFCYGQL 226

  Fly   406 WIKVSTRSIPGESKDAQMDRMQ----QKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKF----- 461
            ...|         |:|...:.:    ||::.:|.:|::.:||.|::.|:|    :|.:.|     
Human   227 VFTV---------KEAAAQQQESATTQKAEKEVTRMVIIMVIAFLICWVP----YASVAFYIFTH 278

  Fly   462 -GSDISQEEFEILKKVMPVAQWLGSSNSCINPILY-SVNKKYRRGFAAIIKSRSCCGRLRYYDNV 524
             ||:..       ...|.:..:...|.:..||::| .:||::|......|    |||:....|:.
Human   279 QGSNFG-------PIFMTIPAFFAKSAAIYNPVIYIMMNKQFRNCMLTTI----CCGKNPLGDDE 332

  Fly   525 AIASSTTSTRKSS 537
              ||:|.|..::|
Human   333 --ASATVSKTETS 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIFaRNP_650966.2 7tmA_CCKR-like 209..505 CDD:320124 67/304 (22%)
TM helix 1 210..236 CDD:320124 6/22 (27%)
TM helix 2 243..269 CDD:320124 9/25 (36%)
TM helix 3 281..311 CDD:320124 4/29 (14%)
TM helix 4 322..340 CDD:320124 5/17 (29%)
TM helix 5 379..404 CDD:320124 8/24 (33%)
TM helix 6 429..459 CDD:320124 9/29 (31%)
TM helix 7 474..498 CDD:320124 5/24 (21%)
RHONP_000530.1 Rhodopsin_N 3..37 CDD:313611
7tmA_MWS_opsin 38..317 CDD:381742 67/304 (22%)
TM helix 1 39..65 CDD:381742 6/22 (27%)
TM helix 2 72..99 CDD:381742 9/26 (35%)
TM helix 3 110..140 CDD:381742 4/29 (14%)
'Ionic lock' involved in activated form stabilization. /evidence=ECO:0000305|PubMed:26200343 134..136 0/1 (0%)
TM helix 4 151..173 CDD:381742 6/21 (29%)
TM helix 5 200..230 CDD:381742 8/29 (28%)
TM helix 6 245..275 CDD:381742 10/33 (30%)
TM helix 7 285..310 CDD:381742 5/24 (21%)
Interaction with SAG. /evidence=ECO:0000269|PubMed:26200343, ECO:0000269|PubMed:28753425 330..348 6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

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