DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIFaR and npffr1l2

DIOPT Version :9

Sequence 1:	NP_001163674.1	Gene:	SIFaR / 42530	FlyBaseID:	FBgn0038880	Length:	758	Species:	Drosophila melanogaster
Sequence 2:	NP_001165168.1	Gene:	npffr1l2 / 570189	ZFINID:	ZDB-GENE-060526-110	Length:	484	Species:	Danio rerio

Alignment Length:	501	Identity:	150/501 - (29%)
Similarity:	253/501 - (50%)	Gaps:	78/501 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 LAGKSLAIADATSSTYYSNLLNLSPATTSLISAAAATKSYNDSALRWEQLDGSVDFGFDPLYRHS 204
            :||:...:..:...|.....::||.|.|:..:|.      |.|::.           :.|.|:||
Zfish     1 MAGEPGEMETSQELTTLDMNISLSNAYTNNSNAT------NHSSIT-----------YYPYYQHS 48

  Fly   205 LAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGN 269
            |.::....:||:.:||:.::||..|..:||...|||||||.||:|||::|:||.|||:|.||:.|
Zfish    49 LPVAAALTLAYLFIFLLCMVGNGLVCLIVLENRRMRTVTNLFILNLAVSDLLVGVFCIPTTLVDN 113

  Fly   270 IFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKRRARIMIIGIWVIA 333
            :...|.....:||....:||:||:|||::|:|:::|||..|.:|.: ::|...|::.|:.|||:|
Zfish   114 LITGWPFTNTVCKMSGLVQGMSVSASVFTLVAIAVDRFRCIVYPFQPKLTLLVAKVTIVMIWVLA 178

  Fly   334 LVTTIPWLLFFDLVPAEEVFSDALVSA----YSQPQFLCQEVWPPGTDGNLY--FLLANLVACYL 392
            :|...|..:   .:..|.|....:|..    ::.|.|.|.|.|.......:|  .|.|::   ||
Zfish   179 VVIMCPSAV---TLTVERVEHHYMVRGEDYNHTYPLFSCFENWANPQMRKVYTTVLFAHI---YL 237

  Fly   393 LPMSLITLCYVLIWIKVSTRSI------------------PGESKDAQMDRMQQKSKVKVIKMLV 439
            :|::||||.|..|.||:.|.|:                  ||..::.: ..:.|| |:||||||.
Zfish   238 IPLTLITLMYGRIGIKLYTTSVISGNDQHDGGQPHTSPQAPGGQQEGR-PLISQK-KIKVIKMLS 300

  Fly   440 AVVILFVLSWLPLYVIFARIKFGSDISQEEFEILK-KVMPVAQWLGSSNSCINPILYS-VNKKYR 502
            .|.:||.:|||||:.:.....:|. ::::|.|:|. .|.|.|.||..|||.:|||:|. .|:.::
Zfish   301 IVALLFTISWLPLWTLMLLTDYGG-LNEDELELLSGYVFPFAHWLAFSNSSVNPIIYGYYNENFK 364

  Fly   503 RGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAVSY-----IYEHN 562
            |||.|:.::.|||     ::.:       :.|:..........:.|:...|.:::     :|...
Zfish   365 RGFQAVCRAHSCC-----FEGM-------TARRGMRRKARGETRDPAVNSNPLNFGARNRVYTDG 417

  Fly   563 SLRRHNMMLKQDSNLSQQMLLKQDSHGSRQFLIKQESSCSDASGIR 608
            .|:.....|:.:...:.::        ....:...|:..|..|||:
Zfish   418 DLKNSGTCLELEHRRTGRL--------CNNSVCSNETGSSVGSGIK 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_001163674.1	7tm_4	216..>443	CDD:304433	91/251 (36%)
SIFaR	NP_001163674.1	7tm_1	225..495	CDD:278431	111/295 (38%)
npffr1l2	NP_001165168.1	7tmA_NPFFR1	53..367	CDD:320647	118/322 (37%)
		TM helix 1	54..80	CDD:320647	9/25 (36%)
		TM helix 2	87..113	CDD:320647	16/25 (64%)
		TM helix 3	125..155	CDD:320647	14/29 (48%)
		TM helix 4	166..187	CDD:320647	8/20 (40%)
		TM helix 5	224..253	CDD:320647	12/31 (39%)
		TM helix 6	290..320	CDD:320647	17/30 (57%)
		TM helix 7	335..360	CDD:320647	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596908
Domainoid	1	1.000	184	1.000	Domainoid score	I3340
eggNOG	1	0.900	-	-		E33208_3BBX5
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24292
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24241
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X258
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.840