DRSC/TRiP Functional Genomics Resources

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Protein Alignment SIFaR and sstr3

DIOPT Version :10

Sequence 1:NP_650966.2 Gene:SIFaR / 42530 FlyBaseID:FBgn0038880 Length:758 Species:Drosophila melanogaster
Sequence 2:XP_695365.1 Gene:sstr3 / 566989 ZFINID:ZDB-GENE-061009-35 Length:480 Species:Danio rerio


Alignment Length:556 Identity:130/556 - (23%)
Similarity:236/556 - (42%) Gaps:125/556 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 ATLAATTTASARGSLAGKSLAIADATSSTYYSNLLNLSPATTSLISAAAATKSYNDSALRWEQLD 190
            |.|...:..|..|.|..:|:     .:.|.:.|:.|.:..|              |:..|.|.  
Zfish    10 AALDIWSNGSIPGFLLNESI-----LNDTCFLNVSNCTNGT--------------DAGNRTET-- 53

  Fly   191 GSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADI 255
                         |:|..::..: ||:|.:|||.|||.||.:||...:..:|||.:|:||||||.
Zfish    54 -------------SMAGILIPLI-YIIVCIVGLGGNSLVIHIVLHYSKTESVTNIYILNLAIADE 104

  Fly   256 LVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLKQMTKR 320
            | .:..||...:.|....|..|...|:.|..:.|::...|::.|..:|:||::|:..|::....|
Zfish   105 L-FMLGLPFLAVQNAMHSWPFGSFTCRLVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIRSSKWR 168

  Fly   321 RARI--MIIG-IWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQPQFLCQEVWP-PGTDGNLY 381
            |.::  .:.| ||.::.:..:|.::|               ::..:...:|..:|| |.......
Zfish   169 RPQVAKAVNGTIWAVSFLVVLPVVIF---------------ASVQREGGICNIIWPKPANVWAAA 218

  Fly   382 FLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQKSKVKVIKMLVAVVILFV 446
            |::......:..|:.:|.:||:||.||:.:   .|:...|...: ::||:.||.:|:|.||.:||
Zfish   219 FIIYTSTVGFFFPLLVICMCYLLIVIKIRS---SGKKVHATSTK-RRKSERKVTRMVVIVVAVFV 279

  Fly   447 LSWLPLYVIFARIKFGSDISQEE-----FEILKKVMPVAQWLGSSNSCINPILYS-VNKKYRRGF 505
            ..|:|.|.:.. |.....:..|.     |.::         |..:|||.|||:|. ::..::|||
Zfish   280 FCWMPFYALNI-INLVESLRDEPQGLHLFVVV---------LSYANSCANPIVYGFLSDNFKRGF 334

  Fly   506 AAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKSPSSKGNAVSYIYEHNSLRRHNMM 570
                 .::.|...|..:|                |:.:.::             :|...||..:|
Zfish   335 -----RKALCRSSRRVEN----------------HEPTEQQ-------------QHQEERRRVLM 365

  Fly   571 LKQDSNLSQQMLLKQDSHGSRQFLIKQESSCSDASGIRRPLCQQDSNGSKVSLSKQDSIVSYMEA 635
            .::  :|.:.:..::|         ::|....:.......:|:...||:.   |.|......:..
Zfish   366 PRE--SLRRAVRDEED---------EEEEEYREEVTEMTEICRITQNGNG---SGQPESTRALFL 416

  Fly   636 RRSAGHGLNDTL-VDRDSVSMD-VGRRQGATPSSLL 669
            .|.:|.|:::.. .||.....| ||:..|..|::.|
Zfish   417 ERPSGTGVSEVCSPDRRGACGDVVGKGPGFGPAATL 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SIFaRNP_650966.2 7tmA_CCKR-like 209..505 CDD:320124 86/305 (28%)
TM helix 1 210..236 CDD:320124 13/25 (52%)
TM helix 2 243..269 CDD:320124 12/25 (48%)
TM helix 3 281..311 CDD:320124 9/29 (31%)
TM helix 4 322..340 CDD:320124 3/20 (15%)
TM helix 5 379..404 CDD:320124 5/24 (21%)
TM helix 6 429..459 CDD:320124 13/29 (45%)
TM helix 7 474..498 CDD:320124 8/24 (33%)
sstr3XP_695365.1 7tmA_SSTR3 58..334 CDD:320638 86/306 (28%)
TM helix 1 59..85 CDD:320638 13/26 (50%)
TM helix 2 92..118 CDD:320638 12/26 (46%)
TM helix 3 129..159 CDD:320638 9/29 (31%)
TM helix 4 171..193 CDD:320638 4/21 (19%)
TM helix 5 216..245 CDD:320638 7/28 (25%)
TM helix 6 262..292 CDD:320638 13/30 (43%)
TM helix 7 302..327 CDD:320638 9/33 (27%)

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