Protein Alignment SIFaR and hcrtr2

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001073337.1
• Gene: hcrtr2 / 561260
• ZFINID: ZDB-GENE-070228-3
• Length: 424
• Species: Danio rerio
• Alignment Length: 433
• Identity: 133/433 - (30%)
• Similarity: 207/433 - (47%)
• Gaps: 72/433 - (16%)

  Fly   145 LAIADATSSTYYS-NLLNLSPATTSLISAAAATKSYNDSALR--WEQLDGSVDFGFDPLYRHSLA 206
            :::..|.:|.:.| ..||.|..|.|...|    ::.:|..|:  |.:            |.|...
Zfish     4 ISVQRACNSCFTSAQHLNSSADTISHSHA----ENEDDELLKYIWRE------------YLHPKQ 52

  Fly   207 MSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPRMRTVTNYFIVNLAIADILVIVFCLPATLIGNIF 271
            ...|....||:||||.|:||:.|...|.:...||||||||||||:.|||||.:.||||:|:.:|.
Zfish    53 YEWVLIAGYILVFLVSLVGNTLVCFAVWKNHHMRTVTNYFIVNLSFADILVTITCLPASLVVDIT 117

  Fly   272 VPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRFIAIWWPLK-QMTKRRARIMIIGIWVIALV 335
            ..|..|..:||.:||:|.:||:.||.:|..::.||:.||..||| :.|.:|||..|:.||:::.:
Zfish   118 ETWFFGQTLCKILPYLQTISVSVSVLTLSCIAQDRWYAICHPLKFKSTAKRARKSIVLIWLVSCI 182

  Fly   336 TTIPWLLFFDLVPAEEVFSDALVSAYSQPQFL---CQEVWP----PGTDGNLYFLLANLVACYLL 393
            ..||..:..:        |.:|:...:....|   |.|.||    |......:|::.     |..
Zfish   183 MMIPQAVVME--------SSSLMPELTNKTSLFTVCDEQWPDEIYPKVYHTCFFIVT-----YFA 234

  Fly   394 PMSLITLCYVLIWIKVSTRSIPGESKDAQ---------------------------MDRMQQKSK 431
            |:.|:.|.|:.|..|:..:.|||.|...|                           .:..|.|::
Zfish   235 PLCLMVLAYIQICHKLWCQQIPGSSSVLQRQWKSLQCSAHAVGSGESVKVRTSTVSAEAKQVKAR 299

  Fly   432 VKVIKMLVAVVILFVLSWLPLYV--IFARIKFGSDISQEEFEILKKVMPVAQWLGSSNSCINPIL 494
            .|..:||:.|:.:|.|.:||:.:  |..|: ||:..:....|.:......:.||..:||..|||:
Zfish   300 RKTARMLMVVLFVFALCYLPISILNIMKRV-FGAFKNTGNRETVYAWFTFSHWLIYANSAANPII 363

  Fly   495 YS-VNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKS 536
            |: ::.|:|..|.|....: |.||...:...|...::|.:|||
Zfish   364 YNFLSGKFREEFKAAFICQ-CSGRGETHKQRARGRTSTDSRKS 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	109/333 (33%)
		TM helix 1	210..236	CDD:320124	12/25 (48%)
		TM helix 2	243..269	CDD:320124	18/25 (72%)
		TM helix 3	281..311	CDD:320124	13/29 (45%)
		TM helix 4	322..340	CDD:320124	6/17 (35%)
		TM helix 5	379..404	CDD:320124	6/24 (25%)
		TM helix 6	429..459	CDD:320124	10/31 (32%)
		TM helix 7	474..498	CDD:320124	8/24 (33%)
hcrtr2	NP_001073337.1	7tmA_OXR	55..375	CDD:320336	109/333 (33%)
		TM helix 1	56..82	CDD:320336	12/25 (48%)
		TM helix 2	89..115	CDD:320336	18/25 (72%)
		TM helix 3	127..157	CDD:320336	13/29 (45%)
		TM helix 4	168..189	CDD:320336	8/20 (40%)
		TM helix 5	220..249	CDD:320336	8/33 (24%)
		TM helix 6	297..327	CDD:320336	10/29 (34%)
		TM helix 7	343..368	CDD:320336	8/24 (33%)
		Orexin_rec2	390..>424	CDD:427531	5/16 (31%)