Protein Alignment SIFaR and npffr1l1

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_001165167.1
• Gene: npffr1l1 / 559950
• ZFINID: ZDB-GENE-091118-18
• Length: 398
• Species: Danio rerio
• Alignment Length: 416
• Identity: 130/416 - (31%)
• Similarity: 215/416 - (51%)
• Gaps: 49/416 - (11%)

  Fly   176 TKSYNDSA--LRWEQLDGSVDFGFDPLYRHSLAMSMVYCVAYIVVFLVGLIGNSFVIAVVLRAPR 238
            |.:.|.||  |.|:...      ..|.|.||..|::.|.::|::|.|:.::||..|..||:|...
Zfish     3 TMTLNHSAANLSWQNCT------LLPYYIHSAGMAVSYILSYLLVLLLCVVGNGLVCLVVIRNRN 61

  Fly   239 MRTVTNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVS 303
            ||:|||.||:|||::|:||.:||:|.|||.::...|....:.|.....:||:||:|||::|:|::
Zfish    62 MRSVTNLFILNLAVSDLLVGIFCVPTTLIDSLISGWPFSQITCTMSNLVQGMSVSASVFTLVAIA 126

  Fly   304 LDRFIAIWWP----LKQMTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVFSDALVSAYSQP 364
            :|||..|.:|    |:.:|   |...|:.||::|.....|......::..::::.......|  |
Zfish   127 VDRFTGIVYPFHHRLRPVT---ALFAIVFIWLLAFAIIFPSAATLTVIHLDDMYMVQNDQIY--P 186

  Fly   365 QFLCQEVWPPGTDGNLYFLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGESKDAQMDRMQQK 429
            .|:|.|.||......:|..:. .|..||.|:.||::.|..|..|:|:        :.|.:|::.:
Zfish   187 LFVCFEDWPRADMRRVYTTVI-FVHVYLAPLGLISIMYGCIAAKLSS--------NLQENRLRSR 242

  Fly   430 SKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGSDISQEEFEILKK-VMPVAQWLGSSNSCINPI 493
            .::||||||:.|.:||::|||||:.:.....: .|:.:::.:.|.. :.|||.||...||.:|||
Zfish   243 RRMKVIKMLIMVAVLFMVSWLPLWTLMLLTDY-QDLDRQQIDFLSSYLFPVAHWLAFFNSGVNPI 306

  Fly   494 LYS-VNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHY-------HQNSSRKSPSS 550
            :|. .|:.:||||.|.:    .||         ..||..|..:.:|:       ..:.||...|.
Zfish   307 IYGFFNENFRRGFQAAV----ACG---------FCSSVASEMRHTHFVLPPPNKVSDGSRGVTSG 358

  Fly   551 KGNAVSYIYEHNSLRRHNMMLKQDSN 576
            :......:..|.:......:|.:|.|
Zfish   359 RKERCFPVIPHGAAHGIQGILLEDMN 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	103/301 (34%)
		TM helix 1	210..236	CDD:320124	9/25 (36%)
		TM helix 2	243..269	CDD:320124	16/25 (64%)
		TM helix 3	281..311	CDD:320124	13/29 (45%)
		TM helix 4	322..340	CDD:320124	5/17 (29%)
		TM helix 5	379..404	CDD:320124	8/24 (33%)
		TM helix 6	429..459	CDD:320124	14/29 (48%)
		TM helix 7	474..498	CDD:320124	11/25 (44%)
npffr1l1	NP_001165167.1	7tm_GPCRs	32..319	CDD:475119	103/301 (34%)
		TM helix 1	34..58	CDD:320647	9/23 (39%)
		TM helix 2	67..89	CDD:320647	12/21 (57%)
		TM helix 3	105..127	CDD:320647	9/21 (43%)
		TM helix 4	148..164	CDD:320647	4/15 (27%)
		TM helix 5	201..224	CDD:320647	7/23 (30%)
		TM helix 6	248..270	CDD:320647	12/21 (57%)
		TM helix 7	287..312	CDD:320647	11/24 (46%)