Protein Alignment SIFaR and NPY4R

DIOPT Version :10

• Sequence 1: NP_650966.2
• Gene: SIFaR / 42530
• FlyBaseID: FBgn0038880
• Length: 758
• Species: Drosophila melanogaster
• Sequence 2: NP_005963.4
• Gene: NPY4R / 5540
• HGNCID: 9329
• Length: 375
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 114/391 - (29%)
• Similarity: 177/391 - (45%)
• Gaps: 65/391 - (16%)

  Fly   179 YNDSALRWEQLDGSVDFGFDPLYRHSLAMSMVYCV-AYIVVFLVGLIGNSFVIAVVLRAPRMRTV 242
            ||.|    |....|||.             ||:.| :|.:..:||::||..::.|.:|......|
Human    28 YNFS----EHCQDSVDV-------------MVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANV 75

  Fly   243 TNYFIVNLAIADILVIVFCLPATLIGNIFVPWMLGWLMCKFVPYIQGVSVAASVYSLIAVSLDRF 307
            ||..|.|||.:|.|:.:.|.|.|.:..|...|:.|..:||...:||.:||..|:.||:.|:|:|.
Human    76 TNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERH 140

  Fly   308 IAI-----WWPLKQMTKRRARIMIIGIWVIALVTTIPWLLFFDLVPAEEVF----SDALVSAYSQ 363
            ..|     |.|    :..:|.:.|:.|||||.|.::|:|....|   |.||    |.||  .:..
Human   141 QLIINPTGWKP----SISQAYLGIVLIWVIACVLSLPFLANSIL---ENVFHKNHSKAL--EFLA 196

  Fly   364 PQFLCQEVWPPGTDGNLY--FLLANLVACYLLPMSLITLCYVLIWIKVSTRSIPGES----KDAQ 422
            .:.:|.|.||......:|  ||   |:..|.||:..|.:||..|:     |.:..:.    |...
Human   197 DKVVCTESWPLAHHRTIYTTFL---LLFQYCLPLGFILVCYARIY-----RCLQRQGRVFHKGTY 253

  Fly   423 MDRMQQKSKVKVIKMLVAVVILFVLSWLPLYVIFARIKFGS--DISQEEFEIL--KKVMPVAQWL 483
            ..|.....:|.|:  ||.:|:.|.:.||||:|      |.|  |...|...|.  ..:..|...|
Human   254 SLRAGHMKQVNVV--LVVMVVAFAVLWLPLHV------FNSLEDWHHEAIPICHGNLIFLVCHLL 310

  Fly   484 GSSNSCINPILYS-VNKKYRRGFAAIIKSRSCCGRLRYYDNVAIASSTTSTRKSSHYHQNSSRKS 547
            ..:::|:||.:|. :|..:::...|::.:......|...:::.:  ||..|..|....:.|.|.:
Human   311 AMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPL--STVHTEVSKGSLRLSGRSN 373

  Fly   548 P 548
            |
Human   374 P 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SIFaR	NP_650966.2	7tmA_CCKR-like	209..505	CDD:320124	98/316 (31%)
		TM helix 1	210..236	CDD:320124	8/26 (31%)
		TM helix 2	243..269	CDD:320124	11/25 (44%)
		TM helix 3	281..311	CDD:320124	13/34 (38%)
		TM helix 4	322..340	CDD:320124	8/17 (47%)
		TM helix 5	379..404	CDD:320124	10/26 (38%)
		TM helix 6	429..459	CDD:320124	11/29 (38%)
		TM helix 7	474..498	CDD:320124	6/24 (25%)
NPY4R	NP_005963.4	7tmA_NPY4R	42..333	CDD:320519	97/315 (31%)
		TM helix 1	43..69	CDD:320519	7/25 (28%)
		TM helix 2	76..101	CDD:320519	11/24 (46%)
		TM helix 3	114..144	CDD:320519	12/29 (41%)
		TM helix 4	155..176	CDD:320519	9/20 (45%)
		TM helix 5	211..240	CDD:320519	11/36 (31%)
		TM helix 6	258..288	CDD:320519	13/37 (35%)
		TM helix 7	301..326	CDD:320519	6/24 (25%)